Fully automated sample preparation system Flex Autoplant

for researchfor the pharmaceutical industrymixing

Overview
The Chemspeed FLEX AUTOPLANT workstations are designed for high-throughput process R&D and preparative synthesis across pharmaceuticals, agrochemicals, polymers, specialty chemicals, catalysts, cathode materials, photovoltaic and storage materials.

• End-to-end process R&D, chemical development and scale-up
• Organic and inorganic synthesis, including reactions under pressure
• Preparative synthesis workflows and work-up
• Crystallization and unit operations integration

Benefits
The FLEX AUTOPLANT workstation enables automated execution of complex, integrated reaction sequences closely mirroring industrial production. It provides configurable reactor arrays, precise feeds and in-line analytics to accelerate development and scale-up.

• Individually controlled tank reactors (volumes: 100, 240, 1,000 mL) with precise continuous feeds
• Up to 6 complete syntheses per run (reaction prep, execution, work-up, analysis)
• Interchangeable stirrer designs (anchor, twisted blade, gas-entrainment) for broad mixing profiles
• Powerful mixing: up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm with anchor stirrer
• Multiple continuous feeds per reactor (liquid, liquefied gas, gas) and unlimited overhead access
• Independent temperature and stirring control per reactor (capable of >130°C difference between adjacent reactors with active cooling)
• Internal or jacket temperature control options
• Pressure capability up to 100 bar with appropriate safety systems
• Parallel calorimetry and viscosity measurements; PAT interfaces (pH, UV-VIS, IR, Raman, PSD, calorimetry)
• Gas consumption measurement, Dean–Stark trap, distillation bridge and vacuum options for inertization, crystallization, etc.
• Ventilated hood for safe handling of sensitive or low-temperature chemistries
• AUTOSUITE software with drag & drop experiment design, Python custom device support and integration to LIMS/ELN/data analysis/AI-ML closed loop
• Optional integrated benchtop NMR (e.g. 80 MHz Fourier RxnLite) and benchtop XRD (e.g. Bruker D6 Phaser, Malvern Aeris) with sample handover and software/hardware integration

Technical specifications

• Product family / model: FLEX AUTOPLANT
• Workstation purpose: high-output process R&D, chemical development, preparative synthesis, work-up and analysis
• Reactor configuration: individually controlled tank reactors; indicated volumes 100 mL, 240 mL, 1,000 mL (total volumes cited)
• Scalability: meta-indication up to 12 individually controlled QbD process reactors (including gravimetric solid & liquid dispensing, work-up, analysis)
• Operational throughput example: up to 6 syntheses per run (including reaction prep, execution, work-up, analysis)
• Stirring: exchangeable stirrers (anchor, twisted blade, gas-entrainment); mixing capabilities as specified above
• Feeds: precise continuous feeds; multiple liquid, liquefied gas and/or gas feeds per reactor
• Temperature control: independent per reactor; internal and/or jacket control; large temperature differentials between adjacent reactors possible
• Pressure: up to 100 bar with corresponding safety installations
• Analytics & PAT: parallel calorimetry, viscosity measurement, PAT probe interfaces (pH, UV-VIS, IR, Raman, PSD, calorimetry)
• Unit operations supported: extraction, filtration, evaporation, crystallization, distillation; Dean–Stark trap; distillation bridge; vacuum for inertization/crystallization
• Safety/environmental: ventilated hood for safe, conditioned operation (sensitive chemicals, low-temperature)
• Software & integration: AUTOSUITE for drag & drop experiment design, LIMS/ELN/data analysis/AI-ML integration; Python custom device support
• Optional instrumentation: benchtop NMR (80 MHz Fourier RxnLite and related capabilities) and benchtop XRD (examples: Bruker D6 Phaser, Malvern Aeris) with sample handover station and full software/hardware integration