Semi-automated sample preparation system AUTOPLANT

fully automatedfor researchfor research and development

Overview
The Chemspeed AUTOPLANT workstations are engineered for high-throughput experimentation to support development and optimization of pharmaceuticals, agrochemicals, polymers, specialty chemicals, catalysts, cathode and photovoltaic materials, storage materials and other chemistries. The platform enables end-to-end process R&D including synthesis, crystallization and preparative workflows.

Workflow / Product family
MULTIPLANT (semi-automated) and AUTOPLANT (fully automated) workflows support integrated reaction sequences and process R&D with configurable reactor and feed arrangements.

Benefits & Features
Each tank reactor operates with independent control and precise continuous feeds:

• Reactor volumes: 100, 240, 1,000 mL; throughput up to 12–24 syntheses per AUTOPLANT run (reaction prep, execution, work-up, analysis) and up to 6 per MULTIPLANT run
• Exchangeable stirrer designs (anchor, twisted/pitched blade, gas-entrainment)
• Mixing capability: up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm with anchor stirrer
• Multiple continuous liquid, liquefied gas and gas feeds per reactor with unlimited overhead access
• Independent, precise temperature and stirring control per reactor; internal and/or jacket control; active cooling enabling >130°C difference between adjacent reactors
• Pressure rating up to 100 bar with appropriate safety installations
• Parallel high-performance calorimetry and viscosity measurements; PAT interfaces for pH, UV-VIS, IR, Raman, PSD, calorimetry; gas consumption measurement
• Unit operations: reaction preparation, execution, work-up, extraction, filtration, evaporation, crystallization, distillation; Dean-Stark trap; distillation bridge; vacuum for inerting/crystallization
• Ventilated hood and conditioned operation for sensitive or low-temperature chemistries
• AUTOSUITE software: drag & drop experiment design, custom device scripting (e.g. Python), integration to LIMS, ELN, data analysis and AI/ML closed-loop workflows; orchestration via ARKSUITE
• Optional integrated online benchtop NMR (e.g. 80 MHz Fourier RxnLite; 1D/2D; H/F/C/P/Si/B nuclei; flow cell or 5 mm tubes; permanent magnet) and benchtop XRD (e.g. Bruker D6 Phaser, Malvern Aeris) with sample handover and software/hardware integration

Technical specifications

• Reactor volumes: 100 mL, 240 mL, 1,000 mL (tank reactors)
• Throughput: up to 12–24 syntheses per AUTOPLANT run; up to 6 per MULTIPLANT run
• Mixing capability: viscosities up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm (anchor stirrer)
• Exchangeable stirrers: anchor, twisted blade, gas-entrainment
• Feeds: multiple continuous feeds (liquid, liquefied gas, gas); precise metering
• Temperature control: independent per reactor; internal and/or jacket; active cooling allowing >130°C difference between adjacent reactors
• Pressure rating: up to 100 bar with safety installations
• Analytics & PAT: pH, UV-VIS, IR, Raman, PSD, calorimetry; parallel calorimetry and viscosity data; gas consumption measurement
• Unit operations: reaction prep, execution, work-up, extraction, filtration, evaporation, crystallization, distillation; Dean-Stark trap; distillation bridge
• Safety: ventilated hood; conditioned operation for sensitive/low-temperature chemistry
• Software & integration: AUTOSUITE; ARKSUITE orchestration; integration to LIMS, ELN, data analysis, AI/ML
• Optional instruments: benchtop NMR, benchtop XRD