Automatic sample preparation system MULTIPLANT FLOWCHEM

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Overview
The leading technology for flexible, automated batch and continuous (flow) chemistry combining quality‑by‑design tank reactors, process control and AUTOSUITE software to accelerate, standardize and digitalize organic process R&D workflows in both batch and continuous modes.

Product summary
Automated all‑in‑one batch and/or flow chemistry platform allowing independent, precise control of process parameters per reactor, multistep reactions with vessel‑to‑vessel transfers, multireactor experiments and optional integrated benchtop NMR for online or offline analysis.

Workflow
Migrated workflow: MULTIPLANT / AUTOPLANT FLOWCHEM

Benefits

• Independent reactor control: tank reactors in 100, 240 and 1,000 mL with separate feed, temperature and mixing settings and precise continuous feeds.
• High experiment throughput: up to 12 / 24 experiments per run on AUTOPLANT; up to 6 per run on semi‑automated MULTIPLANT.
• Combined batch & flow capability enabling multistep reactions and vessel‑to‑vessel transfers on one platform.
• Independent, precise control of feed/flow, temperature and mixing in each reactor.
• Flexible feeds: independent gas, liquefied gas and liquid feeds.
• Accurate dosing: gravimetric solid dispensing and viscous liquid dispensing.
• 4‑Needle Head for volumetric liquid handling and inline/offline sampling.
• In‑process analytics (PAT): IR, PSD, calorimetry, pH and other inline/offline probes.
• Feeding and sampling under reaction conditions, including reflux with optional Dean Stark or distillation; support for elevated pressure reactions.
• Workup options: liquid/liquid extraction, drying, solid‑phase extraction, filtration and evaporation.
• Cleaning‑in‑place (automated) and insert options for simplified maintenance.
• Safety and conditioned operation options: ventilated hood and environmental control for sensitive or low‑temperature chemistries.
• AUTOSUITE software for drag & drop experiment design, extensibility (e.g. Python custom device) and integration with LIMS, ELN, data analysis and AI/ML closed‑loop workflows.
• Optional integrated benchtop NMR for online chemical profiling and data acquisition.

Optional integrated benchtop NMR (summary)

• Includes, for example, an ~80 MHz Fourier RxnLite benchtop NMR.
• Sample introduction via flow cell for online analysis or via standard 5 mm tubes for offline analysis.
• Software with advanced chemical profiling and hardware integration supporting H / F / C / P / Si / B nuclei, 1D and 2D experiments.
• Permanent magnet design (no liquid nitrogen or helium required); 2 Gauss line inside NMR housing.

Technical specifications

• Reactor volumes: 100 mL, 240 mL, 1,000 mL (tank reactors).
• Experiment throughput: up to 12/24 experiments per run on AUTOPLANT; up to 6 per run on semi‑automated MULTIPLANT.
• Modes: automated batch and continuous (flow) chemistry; multistep reactions with vessel‑to‑vessel transfers.
• Feeds: independent gas, liquefied gas and liquid feeds; precise continuous feeds.
• Dispensing: gravimetric solid dispensing and viscous liquid dispensing; 4‑Needle Head for volumetric liquid handling and sampling.
• Process control: independent control of feed/flow, temperature and mixing in each reactor.
• Analytics (PAT): IR, PSD, calorimetry, pH monitoring and other inline/offline tools.
• Reaction capabilities: reflux with optional Dean Stark or distillation; elevated pressure reactions.
• Workup capabilities: liquid/liquid extraction, drying, solid‑phase extraction, filtration and evaporation.
• Maintenance: cleaning‑in‑place (automated, inserts).
• Safety/environment: ventilated hood; conditioned operation for sensitive or low‑temperature chemistries.
• Software: AUTOSUITE for drag & drop experiment design, Python custom device support and integration with LIMS/ELN/data analysis and AI/ML closed‑loop automation.
• Optional NMR: ~80 MHz benchtop NMR (Fourier RxnLite), online flow‑cell acquisition or offline 5 mm tube sampling, supports multiple nuclei and 1D/2D experiments.