Automated sample preparation system MULTIPLANT PRORES

for the pharmaceutical industrydryingfiltration

Overview
The Chemspeed AUTOPLANT PRORES is engineered for high-throughput experimentation in process research, chemical development and scale-up across pharmaceuticals, agrochemicals and fine chemicals.

• End-to-end process R&D and scale-up platform
• Supports organic and inorganic synthesis, pressurized reactions and preparative operations
• Integrated crystallization and downstream unit operations

Capabilities and workflow
Advanced Process Development Workstation technology enables fully automated execution of complex, multi-step workflows to closely replicate industrial production. The system offers flexible reactor configurations and precise control for integrated reaction sequences.

• Individually controlled tank reactors (volumes: 100, 240, 1'000 mL) with continuous, precise feeds
• Up to 12–24 syntheses per AUTOPLANT run (reaction prep, execution, work-up, analysis); up to 6 per semi-automated MULTIPLANT run
• Interchangeable stirrer designs (anchor, twisted blade, gas-entrainment, etc.)
• Mixing capability: up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm with anchor stirrer
• Multiple continuous liquid, liquefied-gas and gas feeds per reactor; unlimited overhead access
• Independent temperature and stirring control per reactor (large delta-T capability, e.g. >130°C between adjacent reactors with active cooling)
• Internal and/or jacketed temperature control
• Pressure capacity up to 100 bar with safety installations
• Parallel high-performance calorimetry and viscosity data acquisition
• PAT interfaces for in-situ probes (pH, UV-VIS, IR, Raman, PSD, calorimetry)
• Gas consumption measurement
• Dean Stark trap, distillation bridge, vacuum for inertisation, crystallization and other operations
• Extraction, filtration, evaporation, crystallization, distillation supported
• Ventilated hood for safe and conditioned operation (sensitive chemistries, low temperatures)
• AUTOSUITE SOFTWARE — drag & drop experimental design; integrations to LIMS, ELN, data analysis and AI/ML closed-loop workflows
• Optional integrated online benchtop NMR (e.g. 80 MHz Fourier RxnLite) supporting H/F/C/P/Si/B nuclei, 1D/2D spectra; online flow cell or offline 5 mm tubes; permanent magnet
• Optional integrated online benchtop XRD (examples: Bruker D6 Phaser, Malvern Aeris) with sample handover station and software/hardware integration

Benefits
Enables high-throughput, high-fidelity process research and scale-up by reproducing industrial conditions, integrating analytics and automation to accelerate development cycles and improve reproducibility.

Specifications / technical features

• Reactor volumes: 100 mL, 240 mL, 1'000 mL (individually controlled)
• Throughput: up to 12–24 syntheses per AUTOPLANT run; up to 6 per semi-automated MULTIPLANT run
• Stirring: anchor, twisted blade, gas-entrainment; mixing up to 80 Pa·s @ 300 rpm and 30 Pa·s @ 900 rpm
• Temperature control: independent per reactor; internal and/or jacket; large delta-T capability (examples >130°C)
• Pressure rating: up to 100 bar (with safety systems)
• Feeds: precise continuous liquid, liquefied-gas and gas feeds; multiple feeds per reactor
• Analytics / PAT: pH, UV-VIS, IR, Raman, PSD, calorimetry; gas consumption measurement
• Unit operations: extraction, filtration, evaporation, crystallization, distillation, Dean Stark trap, distillation bridge, vacuum/inertisation
• Optional integrations: online benchtop NMR (permanent magnet, multi-nuclei, 1D/2D), online benchtop XRD (with handover station)
• Software: AUTOSUITE (drag & drop), integrations to LIMS, ELN, data analysis, AI/ML closed-loop workflows