Rotary ultramicrotome UC Enuity

automatedlaboratoryCryosectioning

Overview

UC Enuity ultramicrotome provides automated setup and sectioning workflows for producing thin and ultra-thin sections for electron microscopy (EM). The system combines motorized controls, targeted trimming and cryo-capable options to streamline laboratory throughput and repeatability.

Key benefits

• Automated workflows: autoalignment of block face and knife, auto trimming and automated setup functions to reduce manual steps and simplify operator training.
• High throughput and consistency for volume EM: prepares uniform ultra-thin and thin ribbons for array tomography and supports direct collection on wafers.
• Flexible targeting: trim toward targets using fluorescence or 3D µCT data to expose a defined plane within the resin block.
• Cryo-capable: integrated cryo chamber and accessories for Tokuyasu and other cryo workflows to minimize ice contamination during cryo sectioning.
• Ergonomics and usability: adjustable system geometry, stereo microscope height/angle adjustment and cushioned arm supports to reduce operator fatigue.
• Upgradeable platform: modular design allows addition of modules (cryo chamber, micromanipulators, cameras, automation modules) to extend functionality.
• RemoteCare: proactive anomaly detection and remote access to critical system parameters to maximize uptime and support troubleshooting.

Intended use

• For research use only.

Features and capabilities (high level)

• Autoalignment of block face and knife (auto approach mode).
• Auto-Trim function to define block boundaries and enable walk-away trimming.
• Motorized segment arc and motorized knife block for precise angle and rotation control.
• Fluorescence monitoring during sectioning at room temperature and cryo to identify regions of interest.
• 3D µCT data import and 3D Trim module to define and reach buried targets precisely.
• Collection options for transferring ribbons and ultra-thin sections to wafers for rapid EM loading.
• Integrated cryo chamber with micromanipulators and cryosphere for reduced ice contamination and stable cryo handling.
• Precise temperature control to maintain consistent cryo conditions.
• Upgradeable add-on modules (cryo chamber, double cryo micromanipulator, cameras, RemoteCare compatibility, etc.).

Configurations (example bundle compositions)
UC Enuity Advance Room Temperature | SKU: uc-enuity-advance-room-temperature | Includes: UC Enuity - Advanced Instrument M80 (16708004); M80 Stereo microscope (16705856); Instrument table with top 0.67 x 1.15 m (16705706); 35° Ultra 3.0mm Auto Knife (16708032); Service Installation (9I_EM_CLASS_D); Routine application training one day (9I_UM_APPLIC1); Warranty Extension (9WE_EM_CLASS_D).

UC Enuity Cryo | SKU: leica-uc-enuity-cryo | Includes: UC Enuity - Basic/Advanced instrument variants; M80 Stereo microscope (16705856); Flexacam Camera (16708052); UC Enuity Cryochamber (16708101); Micromanipulator Cryo Double (16708125); Instrument table (16705706); EM Crion charge/discharge mode (16706042); Service Installation and Warranty Extensions.

Technical specifications

• Product family / model name: UC Enuity.
• Automated setup functions: autoalignment (block face & knife), auto trimming and auto approach mode.
• Motorization: motorized segment arc and motorized knife block for small-angle adjustments and defined rotation steps.
• Section quality: produces semi-thin, thin and ultra-thin sections and uniform ribbons suitable for LM, TEM, SEM and AFM.
• Targeting: supports fluorescence-guided trimming and 3D µCT-based trimming workflows.
• Cryo options: integrated cryo chamber compatible with Tokuyasu and CEMOVIS workflows; support for double cryo micromanipulator.
• Temperature control: precise temperature control to minimize contamination and maintain cooling in humid conditions.
• Collection: direct collection of uniformly aligned ultra-thin sections on wafers to facilitate EM transfer.
• Upgradeability: modular design allowing add-on modules (cryo chamber, cameras, automation modules, etc.).
• RemoteCare capabilities: proactive anomaly detection and real-time monitoring of critical system parameters.
• Intended use: research use only.