Automatic sample preparation system EM ICE

laboratoryfor researchcooling

High pressure freezing is key for the study of intricate changes in fine structure or cellular dynamics. Cryo-immobilize your aqueous samples under high pressure with a unique freezing principle and uncover secrets of the cellular process. Capture and resolve highly dynamic processes at the nanometer scale with millisecond precision. The EM ICE solution, combining superior high pressure freezing with the possibility of light and electrical stimulation, is the platform for your discoveries. Capturelife the moment it happens Coral Life from Leica Microsystems combines live-cell correlative light and electron microscopy (CLEM) with time-specific fixation by high-pressure freezing in a proven and streamlined workflow. This combination enables the investigation of dynamic events with nanometer resolution. Thanks to a seamless interface between high resolution live-cell imaging with the THUNDER Imager Nano and a fast transfer to the EM ICE, precious events can be snap-frozen within seconds. Coral Life provides you an integrated solution, from sample incubation until EM imaging, that will boost your research. Superior cryo-fixation quality Currently cryo-fixation is the only way to fix cellular constituents without introducing significant structural alterations. The EM ICE solution uses a unique, alcohol-free freezing principle to allow a superior cryo-fixation of the specimen enabling better quality results to be obtained: No alcohol in the chamber leads to a faster pressure increase and immediate cooling of the specimen No alcohol residue on the carrier or the specimen Precisely define the timing for light and electrical stimulation