Automatic sample preparation system EM ICE

laboratoryfor researchcooling

High-pressure freezing is essential for detailed analysis of cellular components, as it enables rapid cryo-immobilization of aqueous samples while preserving their ultrastructure. EM ICE combines advanced high-pressure freezing with light and electrical stimulation, making it the ideal platform for groundbreaking discoveries in electron and correlative microscopy. Vitrify for deeper understanding Preserve samples in their native states Preserve your sample’s ultrastructure with EM ICE. High-pressure freezing rapidly immobilizes aqueous specimens, minimizing artifacts and ensuring optimal preservation for downstream cryo-electron microscopy workflows. Freeze your sample for a range of applications Enable accurate structural analysis through cryo tomography workflows to visualize macromolecular complexes within their native environment. Combine high pressure freezing and freeze substitution for various applications including neuroscience, CLEM, cell and developmental biology. Freeze your sample when the important event happens Tailor the EM ICE by combining live cell CLEM, light or electrical stimulation with high-pressure freezing to capture dynamic events. Perform experiments on living sample and immediately freeze it to capture the process. Preserve samples in their native states Cryo-fixation is the only way to fix cellular constituents without introducing significant structural alterations. The EM ICE high pressure freezer uses a unique, alcohol-free freezing principle to allow for a superior cryo-fixation of the specimen enabling better quality results to be obtained: