Pharmacology test kit Octet® GlyM
leadplasmabiological

Pharmacology test kit - Octet® GlyM - Sartorius Group - lead / plasma / biological
Pharmacology test kit - Octet® GlyM - Sartorius Group - lead / plasma / biological
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Characteristics

Applications
pharmacology
Tested parameter
lead
Sample type
plasma, biological, cell
Result display time

60 min, 90 min, 150 min

Description

Designed to analyze both crude and purified samples: no purification or digestion required Relative mannose content screening and ranking of samples into groups: high, medium, or low Glycosylation, an important post-translational modification, is a key critical quality attribute (CQA) that influences product safety and efficacy and should be monitored when developing new biological drugs. Among various glycan structures, mannose is especially important as it affects a protein’s plasma clearance and reduces its in vivo half-life, negatively impacting drug efficacy. While process conditions, media and feed formulations are critical factors in the optimization of protein mannosylation, optimal cell line selection can be a limiting step; early screening for mannose content can facilitate the selection of clones that produce proteins with favorable glycan profiles during cell line development (CLD). The Octet® GlyM Kit enables high-throughput mannose content screening in crude cell culture samples during early clone selection stages in the CLD process. When combined with titer analysis, it expedites the selection of the top performing cell lines producing proteins with the most favorable glycan (mannose) profile. Only clones which are the most suitable will move downstream for further optimization. Reliable data at this early stage supports shorter lead times and prevent later failures.

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