Short-term absorbable suture thread Premisut PGLAR-910

general surgeryoral surgeryophthalmic surgery

Overview
Premisut PGLAR-910 suture (Polyglactin 910) is a sterile, synthetic, multifilament braided fast absorbable surgical suture manufactured from a co-polymer of 90% glycolide and 10% L-lactide. The material used has a lower molecular weight than standard PGLA formulations, resulting in a faster absorption profile and rapid loss of tensile strength after implantation. The suture is supplied undyed and is coated with a mixture of Polyglactin 370 co-polymer and calcium stearate to improve lubrication, facilitate smooth passage through tissue and aid knot security.

Intended use and clinical applications
Premisut PGLAR-910 is intended for general soft tissue approximation where only short-term wound support is required and where rapid absorption is advantageous. Typical applications include skin closure (notably in paediatric surgery), episiotomy repair, circumcision, closure of oral mucosa and conjunctival suturing in ophthalmic procedures.

Tissue reaction and absorption
After implantation the suture elicits a mild to moderate initial inflammatory response and is progressively replaced by fibrous connective tissue. Absorption occurs by hydrolysis: the Polyglactin 910 co-polymer degrades into glycolic and lactic acids, which are metabolized and eliminated by the body. The absorption process is associated first with a progressive loss of tensile strength and subsequently with mass loss.

Handling and packaging
Premisut PGLAR-910 is supplied sterile and, as a braided multifilament, offers good handling and knot security when properly tied. The coating promotes smooth tissue passage and ease of knot tying. Needle type, suture sizes and packaging options may vary by market and by clinical requirement.

Notes
Technical characteristics (for example coating, tensile strength, needle composition and packaging) may be adjusted to meet specific market or regulatory requirements.

Characteristics / Technical specifications

• Material: Polyglactin 910 co-polymer (90% glycolide, 10% L-lactide)
• Absorption profile: fast absorbable; rapid loss of tensile strength after implantation
• Structure: sterile synthetic multifilament braided suture
• Color: available undyed
• Coating: mixture of Polyglactin 370 co-polymer (30% glycolide, 70% lactide) and calcium stearate for lubrication and smooth passage
• Clinical uses: short-term soft tissue approximation; skin closure (including paediatric), episiotomies, circumcision, oral mucosa closure, conjunctival suturing (ophthalmic)
• Biodegradation: hydrolysis to glycolic and lactic acids, followed by metabolic absorption