Solution reagent AS3804

for clinical chemistryliquidAST

The Randox AST assay displayed a within run precision of < 4.96% Liquid ready-to-use The Randox AST assay is available in a liquid ready-to-use format for convenience and ease-of-use. Calibrator and controls available Calibrator and controls available offering a complete testing package.. Applications available Applications available detailing instrument-specific settings for the convenient use of the Randox AST assay on a variety of clinical chemistry analysers. (L) Indicates liquid option Instrument Specific Applications (ISA's) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser. Clinical Significance Physiological Significance Enzymes are organic molecules responsible for the acceleration of biochemical reactions, however, emerge unchanged following the reaction. Aminotransferases are a family of enzymes that catalyse the conversion of amino acids to 2-oxo-acids by the transfer of amino acids 1. AST is present in mitochondrial and cytosolic enzymes (80% and 20% of activity respectively), found in brain, cardiac muscle, kidneys, leucocytes, liver, lungs, red blood cells and skeletal muscle 2. Hepatic Function AST is a marker of hepatocellular injury, predominantly alcohol-related liver injury (chronic hepatitis C) and cirrhosis (chronic hepatitis B). In alcoholic liver disease, P-5-P becomes deficient, which is greater on ALT activity compared to AST activity. Consequently, ALT activity is reduced, whereas AST activity is increased 2. The hallmark finding for alcohol liver disease is the AST to ALT ratio of at least 2:1 3.