Clinical chemistry assay kit BI series

for bile acidenzymaticcolorimetric

The Randox Bile Acids method is linear up to a concentration of 150 µmol/l Exceptional correlation with standard methods The Randox methodology was compared against other commercially available methods and the Randox Bile Acids assay showed a correlation coefficient of 0.99 Flexibility Liquid and lyophilised reagents available for greater customer choice Analyser protocols Protocols are available for a range of analysers Excellent stability Stable to expiry when stored at +2 to +8°C Liver Function Measuring total bile acid (TBA) levels may prove useful for the detection of liver diseases such as viral hepatitis, mild liver injury through drug use and for further evaluation of patients with chronic hepatitis who were previously treated successfully. TBA levels may rise up to 100 times the normal concentration in patients with liver disease due to impairment of hepatic synthesis and extraction of bile acids. Measurement of TBA in serum can be used in the diagnosis and prognosis of liver diseases and may detect some forms of liver disease earlier than standard liver markers due to the correlation of TBA with liver function, rather than liver damage. Bile Acid Deficiency TBA deficiency is caused by a genetic error in one of the 17 enzymes that produce bile acids. Deficiency can lead to liver failure and even death in infants, therefore early detection is vital. People with TBA deficiency may exhibit symptoms, including: • Vitamin deficiencies, specifically of fat-soluble vitamins such as A, D, E, and K • Jaundice • Stunted or abnormal growth • Diarrhoea • Loss of liver function • Liver failure