Rapid infectious disease test SC-0531-25

dengue feverIgGIgM

The Dengue Combo Cassette Test (Whole Blood/Serum/Plasma) is a rapid chromatographic immunoassay for the qualitative detection of NS1 antigen and Dengue virus IgG and IgM antibodies in human whole blood, serum or plasma, as an aid in diagnosing Dengue infections. Dengue is a flavivirus, transmitted by the Aedesaegypti and Aedesalbopictus mosquitoes, widely distributed in tropical and subtropical areas of the world, causing up to 100 million infections per year. Classic Dengue infection is characterized by a sudden onset of fever, intense headache, myalgia, arthralgia, and rash. Primary Dengue infection causes IgM antibodies to rise to a detectable level 3-5 days after the onset of fever. IgM antibodies generally persist for 30 to 90 days.3 Most Dengue patients in endemic regions have secondary infections, resulting in elevated levels of specific IgG antibodies that precede or appear simultaneously with the IgM response. Therefore, the detection of specific anti-Dengue IgM and IgG antibodies can also help distinguish between primary and secondary infections. NS1 is one of the 7 non-structural proteins of the Dengue Virus believed to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is believed to be involved in viral replication. The remainder of NS1 is found to be associated with the plasma membrane or secreted as a soluble hexadimer. NS1 is essential for viral viability but its precise biological function is unknown.