Automated sample preparation system SRS 100i

laboratoryfor HPLCfor sample preparation

Overview
The Sample Recovery System™ SRS 100i delivers a controlled, standardised approach to drug recovery for OINDP (orally inhaled and nasal drug products) testing. It reduces variability across analysts and sites and produces traceable, HPLC-ready samples for Delivered Dose Uniformity (DDU) and Aerodynamic Particle Size Distribution (APSD) workflows. The system automates solvent dispensing, dissolution and sample collection to streamline laboratory throughput and data integrity.

Key benefits

• Reproducible drug recovery across analysts and sites
• Controlled solvent dispensing and dissolution
• Reduced manual handling and hands-on recovery time
• HPLC-ready samples for immediate analysis
• Configurable to suit most laboratory workflows
• Eliminates risk of cross-contamination
• Aligns with established recovery methods
• Designed for regulated environments (supports 21 CFR Part 11 and GMP requirements)

How it works — Four-step automated recovery workflow

• 1. Load: Test components are placed into dedicated holders within the system.
• 2. Dispense: Defined volumes of solvent are delivered to each component and collection surface.
• 3. Dissolve: Controlled solvent delivery and rinsing support consistent recovery using established methods.
• 4. Collect: Prepared samples are aspirated into HPLC vials, ready for immediate analysis.

Product highlights

• Reproducible execution of recovery steps to reduce operator-dependent variability
• Controlled dispensing accuracy and agitation to support consistent extraction
• Long run time capability for extended processes (batch/overnight)
• Interfacing options for data transfer and integration with data management workflows
• Compatibility with Inhalytix®+ for method and operational parameter transfer and unified, traceable workflows

Frequently Asked Questions

• Why automate drug recovery in inhaler testing? — Manual recovery depends on operator technique and can introduce variability. Automation standardises key steps for controlled, repeatable execution and improved confidence in results.
• How does the SRS 100i improve reproducibility? — By controlling solvent dispensing, dissolution and sample handling, the system replaces manual intervention with a defined, repeatable workflow delivering consistent results across runs, analysts and sites.
• Can the SRS 100i be used for DDU and APSD workflows? — Yes. It supports drug recovery for both DDU and APSD testing, working with standard components such as DUSA systems, impactors, induction ports and preseparators.
• How does the system support data integrity? — Standardising solvent delivery, dissolution and sample handling reduces operator-dependent variation. Compatibility with data-management platforms enables transfer of method parameters and operational data to support traceable datasets.
• Does the SRS 100i support regulatory compliance? — The system is designed for use in regulated environments and supports controlled, repeatable processes with electronic records functionality to help meet regulatory requirements.

Technical specifications

• Dispensing accuracy: ± 1%
• Agitation speed: 10–60 RPM (± 1 RPM)
• Run time: Up to 24 hours (up to 60,000 revolutions)
• Connectivity: USB A, USB B, RS232 (run in digital input)
• Dimensions (W x D x H): 590 x 320 x 235 mm