Semi-automatic dissolution tester IDA

for the pharmaceutical industryfor in-vitro drug releaselaboratory

Overview
Inhaled dissolution testing determines how an aerosolised drug dissolves after deposition and supports assessment of inhaled product performance and comparative studies. The Inhaled Dissolution Apparatus™ IDA is a purpose-built platform that enables repeatable, comparable dissolution profiles from aerosolised samples using a standardised Collect – Transfer – Dissolve workflow. Patent pending.

Key product highlights

• Repeatable, comparable dissolution data for inhalation formulation assessment
• Discriminatory performance to detect meaningful formulation differences
• Designed specifically for orally inhaled products (OIPs)
• Optimised paddle and flat-bottom vessel geometry for OIP-relevant media volumes
• Flexible inlet compatibility with common collection configurations
• Integrated dissolution testing platform with minimal manual handling
• Automation compatible (e.g. Vertus® III)
• Performance supported by scientific data

Purpose-built dissolution workflow
The IDA is built around a simple, standardised 3-step workflow to streamline testing and minimise sample handling: Collect → Transfer → Dissolve. This approach reduces handling-related variability and improves comparability across studies and laboratories.

How the IDA works: a simple 3-step process

• Step 1: Collect – The aerosolised drug is collected onto a filter using the selected inlet configuration to ensure consistent dose capture.
• Step 2: Transfer – A dedicated filter holder transfers the collected sample directly into the dissolution setup by attaching to the dissolution paddle, minimising manual contact.
• Step 3: Dissolve – The filter is lowered into the dissolution vessel containing media and dissolution profiling is performed under controlled conditions. The flat-bottom vessel and adapted paddle geometry maintain consistent circulation for OIP-relevant volumes.

Additional notes
The IDA supports alternative integration options such as dissolution cups and watchglass/PTFE assemblies to work with established OIP collection configurations. Reported data demonstrate repeatable formulation discrimination and robust comparative performance.

Technical specifications

• Flow rate compatibility: 5 – 100 L/min
• Flow profile options: constant flow and breathing simulation (tidal / inhalation-only)
• Inlet compatibility: NGI Induction Port, NGI Preseparator, Fast Screening Impactor, Alberta Idealised Throat, Alberta Idealised Nasal Inlet (AINI), Glass Expansion Chambers
• Stations available: 6 or 8 stations
• Media volume range: 200 – 500 mL
• Automation compatibility: compatible with automated shake-and-fire systems (e.g. Vertus® III)