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Alzheimer biomarkers, PHF-Tau One of the key hallmarks to Alzheimer’s disease is the formation of neurofibrillary tangles. These are aggregates of hyperphosphorylated Tau protein, also referred to as paired helical filaments (PHF-Tau). The ...
Alzheimer biomarkers, Tau Tau proteins are mainly present in neurons and play a role in axonal microtubule stability. An increase of Tau is considered as a biomarker for neuronal death and as such often included in diagnostic algorithms ...
α-fetoprotein (AFP) is produced during embryonic development and found in high concentrations in fetal serum. AFP has been shown to be elevated in patients with hepatocellular carcinoma. The AFPK57, AFPK51, and AFPK52 monoclonal antibodies ...
The CA125 monoclonal antibodies recognize epitopes in the protein core of the CA125 antigen. These monoclonal antibodies show high specificity for ovarian cancer, and can be used for development of fast and sensitive homologous or heterologous ...
The MUC-1 breast cancer antigen is a mucin-type glycoprotein. It is secreted from tumor cells and can be used as a serological marker of breast cancer. The Ma552 and Ma695 antibodies to MUC-1 were characterized in the ISOBM TD4-workshop. ...
The CanAg CA19-9 EIA is based on a mouse monoclonal antibody, C192, highly specific for the sialyl Lewisa epitope, also known as CA19-9 antigen1. In adults, the epitope is typically expressed in trace amounts on mucosal cells of gastrointestinal ...
The tumor marker CA242™ is defined by the monoclonal antibody C242™. The chemical structure of the antigenic determinant is not exactly known, but the determinant has been shown to be a sialylated carbohydrate structure. In serum, CA242™ ...
S100 is a 10 kDa protein belonging to the S100/calmodulin/troponin C superfamily of EF-hand calcium-binding proteins. S100 was originally isolated from bovine brain and considered a glial-cell specific protein (1). Today, 20 monomers ...
Squamous cell carcinoma antigen (SCC ag) is a group of glycoproteins with molecular weight ~45 kDa, belonging to the family of serine/cysteineprotease inhibitors1. The protein was originally isolated by Kato and coworkers from human squamous ...
Carcinoembryonic antigen (CEA) is a glycoprotein, which was first identified in patients with colon carcinoma and in epithelial tumors of endodermal origin (gastrointestinal tract) by Gold and Freedman1. The CEA molecule is quite heterogeneous ...
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