Automatic dissolution tester ATS Xtend™ Double UV Online

for the pharmaceutical industryUV/VIS

Product overview
The ATS Xtend™ Double UV Online provides real-time UV-Vis analysis for two dissolution testers using a single spectrophotometer. It performs simultaneous single- or multi-wavelength measurements and supports up to 16 samples per timepoint. Withdrawn volumes can be immediately returned to vessels to maintain closed-loop sampling for delayed- or modified-release methods.

Key benefits

• DOUBLE CAPACITY - Run two dissolution tests in parallel and analyze up to 16 samples in real time
• SCALABLE - Increase capacity with identical modules to minimize validation effort
• RESOURCE EFFICIENT - Share one UV-Vis spectrophotometer between two baths
• PHARMACOPOEIA-COMPLIANT - True double-beam UV-Vis with cooled double detection (CDD) exceeding pharmacopeia requirements
• REAL-TIME ANALYSIS - Simultaneous single or multi-wavelength measurement of dissolution samples
• CLOSED-LOOP SAMPLING - No media replacement required for DR and MR multi-timepoint methods
• 21 CFR PART 11 READY - Supports compliant data management workflows

Highlights

• Real-time analysis for up to 16 vessels with immediate return of withdrawn volumes
• Share one spectrophotometer: connect two Xtend™ baths to a single UV-Vis with automated cuvette changer
• Flexible sampling: motorized AutoLift™, through-shaft HollowShaft™, or stationary cannulas; compatible with cannula, disc or syringe filters
• Automated sampling available with AutoLift™, HollowShaft™ or fixed cannulas for AT Xtend dissolution testers
• CP piston pump option for pushing through filters and handling foaming media; integrates with Specord® UV-Vis for immediate measurement
• MPS media station for degassing, heating and dispensing 10–20 L of medium to dissolution baths

Modules & options (examples)

• AT dissolution tester (Xtend™ dissolution bath)
• CP piston pump (for filters and foaming media)
• Specord® UV-Vis (double-beam spectrophotometer with CDD)
• q-doc® software (data management with 21 CFR part 11 features)
• WinSOTAX®plus (dissolution method and reporting software)
• MPS media station (mobile media preparation: heat, degas, dispense)
• FS filter station (automated syringe filter change)
• IPC peristaltic pump (for non-critical UV online applications)
• CenterView™ (video monitoring per vessel)

Applications

• Real-time UV-Vis dissolution testing for USP 1/2/5/6 and similar methods
• Closed-loop sampling for delayed-release (DR) and modified-release (MR) formulations
• High-throughput workflows: up to 16 samples per timepoint, two baths per spectrophotometer

Technical specifications

• Simultaneous analysis: up to 16 samples in real time
• Shared UV-Vis configuration: connects two Xtend™ baths to one spectrophotometer with automated cuvette changer
• Spectrophotometer: double-beam UV-Vis with cooled double detection (CDD), e.g., Specord®
• Sampling methods: AutoLift™, HollowShaft™ (through-shaft), stationary cannulas
• Pumping options: CP piston pump (for filters/foaming media) and IPC peristaltic pump (for non-critical products)
• Filtration: cannula, disc or syringe filters; FS filter station for automated changes
• Media handling: MPS media station supplies 10–20 L degassed and heated medium, prevents re-aeration
• Compliance: designed to meet pharmacopeia requirements and supports 21 CFR part 11 via q-doc® and WinSOTAX®plus
• Automation concept: modular Xtend™ architecture for scalable, identical-module expansion