Fully-automatic dissolution tester ATF Xtend™ UV On-/Offline

for capsulesfor medical researchlaboratory

Product Overview
Fully automated dissolution tester with integrated UV-Vis analysis and flexible offline sample collection. The system combines online real-time dissolution measurement with the possibility to collect samples in tubes, capped LC vials or wellplates for offline analysis. It integrates media preparation, vessel filling, automated sampling, filtration, and system cleaning to provide a compact end-to-end solution.

Key Benefits

• Flexible workflow supporting integrated UV-Vis for immediate analysis or automated sample collection for offline processing.
• Design of Experiment (DOE) support and straightforward comparison of test results across analytical finishes.
• Repeatable, protocol-driven test execution from media preparation to sampling and filtration.
• Real-time dissolution profiles and percent dissolved outputs using double beam or diode array UV-Vis technology.
• Compliance-focused design meeting USP and Ph.Eur. requirements with AutoCompliance™ features.
• Data integrity through automatic execution and recording of every step.
• Compact footprint for installation in R&D and QC laboratories.

Automation
The system automates the complete dissolution workflow: preparing and degassing/heating dissolution media, precise vessel filling with gravimetric verification, automated sampling (online and offline), filtration, and customizable robust washing/cleaning routines at the end of each run. Options include vacuum degassing or helium de-aeration and returns of withdrawn volumes to vessels when required.

Highlights

• Automated vessel filling and spray-cleaning with gravimetric verification of delivered volumes.
• Combine online UV-Vis measurement and offline sample collection for backup or comparative analysis; safe storage for multi-component products across 30–60 timepoints depending on configuration.
• Real-time UV-Vis integration supporting double beam (Specord®) or diode array (UV7) spectrophotometers for immediate analytical data and consolidated reporting.
• Data integrity features including protocolled methods, automatic execution, and optional CenterView™ video monitoring for each vessel.
• AutoCompliance™ design with fixed shaft height, self-centering vessels and MQD™ tool support for mechanical qualification routines.

Modules & Key Components

• AT-F bath: integrated module with vessel filling, sampling and cleaning functions.
• MP-F media station: prepares, heats and degasses dissolution media (vacuum or helium options).
• CP-F piston pump: powerful sampling pump to handle filters and foaming media.
• FS-F filter station: automatic filter exchange for multiple test runs.
• CS-F cleaning station: spray cleaning and automated emptying of vessels.
• UV7 UV-Vis: compact diode array spectrophotometer for UV Online.
• Specord® UV-Vis: high-performance double beam spectrophotometer (optional).
• SAM sample manager S: offline sample collection in tubes, capped LC vials, and wellplates.
• RS robotic station: automated basket exchange and sinker retrieval for USP 1/2.
• q-doc® software: integrated data management with built-in 21 CFR part 11 compliance.

Applications
Designed for dissolution testing according to USP 1/2/5/6 and Ph.Eur. methods across a wide range of dosage forms, enabling both R&D (DOE) workflows and routine QC testing with full documentation and data integrity.

Technical specifications

• Model family: ATF Xtend™ platform with UV On-/Offline configuration.
• Integrated analytical options: double beam (Specord®) or diode array (UV7) UV-Vis spectrophotometers.
• Offline collection: tubes, capped LC vials, wellplates; capacity and storage for 30–60 timepoints depending on configuration.
• Automated modules: AT-F bath, MP-F media station, CP-F piston pump, FS-F filter station, CS-F cleaning station, SAM sample manager S, RS robotic station.
• Media preparation: heating and degassing by vacuum or helium; precise volumetric and gravimetric filling with verification.
• Sampling: automated online sampling with immediate analysis or sample capture for offline analytics; withdrawn volumes can be returned to vessels where applicable.
• Cleaning & validation: robust customizable washing routines; support for MQD™ tool and mechanical qualification per guidelines.
• Compliance & data integrity: AutoCompliance™ design, support for USP and Ph.Eur., methods and recipes managed and executed reproducibly; compatible with 21 CFR part 11 when used with q-doc® or equivalent software.
• Data outputs: real-time dissolution profiles, percent dissolved calculations, consolidated test run reports.
• Form factor: compact fully automated system optimized for minimal footprint.