Fully-automatic dissolution tester ATS Xtend™ UV Online

for the pharmaceutical industrylaboratoryUV/VIS

Product overview
The ATS Xtend™ UV Online integrates an online UV-Vis spectrophotometer with a dissolution tester to deliver real-time concentration measurement for each sampling timepoint. The system performs parallel analysis of multiple vessels, returns withdrawn volumes to the vessels (closed-loop sampling), and consolidates UV-Vis results and protocolled test conditions into a single report.

Benefits

• Immediate access to dissolution profiles with live data display for faster decision-making and reduced analysis turnaround.
• High-frequency sampling capable of reading as often as every 60 seconds per vessel for methods requiring short timepoints (e.g., modified-release).
• Closed sampling loop: withdrawn volumes are returned to the vessel after measurement, avoiding media replacement for many DR/MR protocols.
• Multi-component and single-wavelength analysis supported for simultaneous quantification across samples.
• Flexible integration with different spectrophotometer technologies (double beam CDD or diode array).
• Consolidated data integrity: all spectral results and recorded test conditions are stored in one test report.
• Networkable systems to share methods, aggregate batch records and simplify user administration.

Highlights & key features

• Parallel analysis: analyze 6–8 dissolution samples in parallel per sampling point with automatic consolidation of results into a single report.
• Simultaneous sampling: motorized AutoLift™ cannulas, HollowShaft™ or resident probes enable flexible sampling; samples are returned immediately after measurement.
• Spectrophotometer integration: supports high-performance double-beam (CDD) instruments and fast diode-array spectrometers for single-wavelength, multi-component or full-scan analyses.
• Simplified cleaning: multi-media valve and automated flushing of sample lines and tubing for efficient post-test maintenance.
• Data management & networking: share user groups and methods, consolidate batch records and simplify reporting using integrated software solutions.

Automation
The ATS Xtend™ UV Online supports fully automated sampling workflows including motorized AutoLift™ sampling cannulas, HollowShaft™ sampling, resident probe sampling, automated return of withdrawn volumes and programmable sampling intervals down to 60 seconds per vessel depending on configuration and spectrophotometer performance.

Modules & compatible options

• AT dissolution tester (Xtend™ dissolution bath) - base dissolution bath prepared for manual, semi-automated and automated workflows.
• CP piston pump - high-performance piston pump for filter push-through and foaming media handling.
• Specord® UV-Vis - double-beam spectrophotometer with CDD for high-precision UV-Vis integration.
• UV7 UV-Vis - compact diode-array spectrophotometer for fast full-scan applications.
• q-doc® software - 21 CFR Part 11-compliant data management for method, results and report consolidation.
• WinSOTAX®plus - dissolution software for method and report management.
• MPS media station - mobile media preparation station for heating, degassing and dispensing media.
• FS filter station - automated syringe filter changer for multi-timepoint methods.
• IPC peristaltic pump - simple peristaltic option for non-critical applications.
• CenterView™ - video monitoring option for individual vessels.

Downloads & media
Product page provides videos and brochures; access to some PDF downloads may require authorization.

Technical specifications

• Parallel analysis: supports 6–8 dissolution samples in parallel per sampling point.
• Sampling interval: sampling as often as every 60 seconds per vessel (configuration and spectrophotometer dependent).
• Supported spectrophotometer types: double-beam (CDD) and diode-array UV-Vis instruments with full-scan capability.
• Sample handling: closed-loop sampling with return of withdrawn volumes to vessels after measurement.
• Automated cleaning: multi-media valve for automated flushing of sample lines and tubing.
• Integration: supports automated cuvette changers and automated sample handling modules.
• Data management: consolidation of UV-Vis results and protocolled test conditions into single test reports; compatible with q-doc® and WinSOTAX®plus.
• Sampling modules/options: AutoLift™ cannulas, HollowShaft™, resident probes, CP piston pump, IPC peristaltic pump, FS filter station, MPS media station, CenterView™ video monitoring.
• Networking: supports networked dissolution testers to share methods and consolidate batch records.