Automatic dissolution tester ATS Xtend™ UV On-/Offline

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Product Overview
The ATS Xtend™ UV On-/Offline dissolution tester combines online UV-Vis measurement with offline sample collection for dissolution testing. It enables alternating tests with online analysis and offline collection without change-over of tubing. Measured samples can be collected for comparison of analytical finishes or other purposes.

Key Benefits

• FLEXIBILITY - Delivers real-time UV-Vis results and collects samples in tubes, capped LC vials, or wellplates.
• ONLINE - Single wavelength or multi-component analysis with integrated UV-Vis spectrophotometer.
• FAST - Sample and measure as often as every 60 seconds in each vessel for multi-timepoint methods.
• COMPARE - Collect measured samples to easily compare analytical finishes.
• DATA INTEGRITY - Automatically report measured UV-Vis results together with protocolled test conditions.
• COMPLIANT - Fulfills Pharmacopeia and 21 CFR part 11 requirements for electronic records keeping.
• UV-VIS - Integrate the UV-Vis technology of your choice - double beam or diode array.

Highlights

• Combines the efficiency of online UV-Vis measuring with the flexibility of offline sampling; switch between online analysis and offline collection without tubing change-over.
• Choose your UV-Vis: options include fast diode array spectrophotometers (e.g., Mettler Toledo UV7) or true double beam UV-Vis (Specord) enabling full scans in each vessel.
• Sampling line cleaning: equipped with a media selector to replace withdrawn sampling volumes for delayed release methods, add media for pH changes, and run automated cleaning routines to flush all sampling lines without disconnecting tubing.
• Filtration & collection: configured with CP piston pump technology to push through filters down to 0.2 µm and handle foaming media; supports tip, disc and syringe filters and collects samples for HPLC/UPLC.
• Scalable data management: integration with q-doc® or WinSOTAX®plus for reporting UV-Vis results together with protocolled test conditions; built-in 21 CFR part 11 compliance and role segregation.

Modules & Options

• AT dissolution tester (Xtend™ bath) with flexible sampling and monitoring functions.
• CP piston pump for powerful, maintenance-light pumping capable of driving filters and foaming media.
• UV7 UV-Vis (diode array) for compact, fast online measurements.
• SAM-SR sample manager to collect samples in tubes, capped LC vials and wellplates.
• FS filter station for automated syringe filter changes in multi-timepoint methods.
• MPS media station for mobile media preparation (heat, degas, dispense).
• CenterView™ video monitoring option for dissolution process observation in each vessel.
• Software options: q-doc® and WinSOTAX®plus for method, data and report management with compliance features.

Technical specifications

• Sampling frequency: measurements and/or sample collection as often as every 60 seconds per vessel.
• UV-Vis options: diode array (e.g., Mettler Toledo UV7) or double beam (e.g., Specord) with full scan capability (UV7 wavelength range cited 190 - 1100 nm).
• Sample collection formats: tubes, capped LC vials, wellplates.
• Filtration capability: handles filters to 0.2 microns; supports tip, disc, and syringe filters.
• Pump technology: CP piston pump providing high pressure to push through fine filters and manage foaming media.
• Media handling: media selector supports automated replacement of withdrawn volumes, pH change additions, and one-touch sampling line cleaning routines.
• Data management & compliance: integration with q-doc® and WinSOTAX®plus; compliant with 21 CFR part 11 and FDA data integrity guidelines (segregation of roles, electronic records).
• Automation capability: modular options to automate vessel filling, emptying and cleaning routines.