Fully-automatic dissolution tester ATF Xtend™ Offline

for capsulesfor medical researchfor in-vitro drug release

Product Overview
The ATF Xtend™ Offline is a dissolution tester designed for unattended, fully automated R&D and QC workflows. It integrates inline media preparation, precision sampling with filtration, and an automatic cleaning sequence while enabling offline sample collection for HPLC/UPLC analysis.

Key benefits

• 100% UNATTENDED — Execute multiple dissolution runs without operator intervention.
• 100% TRACEABLE — Automatic execution and logging of media preparation, sampling and cleaning steps.
• 100% REPEATABLE — Consistent vessel filling, sampling, filtration and wash routines for reproducible results.
• MEDIA MANAGEMENT — Inline preparation, heating and degassing of media with volume replacement and pH adjustment capabilities.
• FINE FILTRATION — High‑precision piston pumps enable push‑through filtration down to 0.2 µm for reliable HPLC/UPLC samples.
• AUTOMATIC CLEANING — Self‑cleaning routines empty and spray vessels between runs to minimise carryover.
• SAMPLE COLLECTION — Offline collection into test tubes, capped LC vials or wellplates from up to 60 timepoints.

Automation
The system automates routine and complex dissolution workflows: media preparation (heating, degassing, dosing), gravimetric verification of vessel volumes, integrated sampling with filtration, sample handling and automated spray cleaning between runs. Continuous operation allows preparing subsequent series while earlier sequences are running.

Highlights

• True automation of laborious steps including gravimetric vessel filling, integrated sampling and full‑system cleaning between runs.
• Inline media station supports multiple recipes and deaeration methods (vacuum or helium sparging).
• SmartAdd™ tablet magazine permits loading or exchanging tablet magazines during a sequence to reduce downtime.
• Integrated SAM autosampler collects samples in tubes, capped vials or HPLC/UPLC wellplates with optional flow‑through rack cooling.
• Compliance by design: fixed sampling positions, shaft height control and vessel centering; supports data management compliant with 21 CFR Part 11 and harmonized pharmacopeia.

Modules

• AT-F bath — Integrated module for vessel filling, sampling and cleaning functions.
• MP-F media station — Inline media preparation, heating and degassing according to recipes.
• CP-F piston pump — High‑performance piston pump for push‑through filtration and foaming media handling.
• FS-F filter station — Automatic filter exchange for multiple consecutive runs.
• CS-F cleaning station — Spray‑cleaning and vessel emptying module.
• SAM sample manager — Offline sample collection module (30–60 timepoints) supporting tubes, capped vials or wellplates with cooling.
• q-doc® software — Centralized data management with audit trail and regulatory features.

Options

• CenterView™ — Video monitoring of the dissolution process per vessel.
• RS robotic station — Automated basket exchange (USP 1) and sinker retrieval to further reduce manual tasks.

Technical specifications

• Model name: ATF Xtend™ Offline
• Operation mode: Fully automated, unattended sequences
• Media preparation: Inline preparation, heating and degassing; vacuum deaeration or helium sparging options
• Filtration capability: Fine filtration down to 0.2 µm (with CP-F piston pumps)
• Sample collection: Offline into test tubes, capped LC vials or wellplates; up to 60 timepoints
• Sample manager capacity: ~30–60 timepoints (configuration dependent)
• Cleaning: Integrated spray cleaning and vessel emptying between runs (CS-F)
• Pumps: CP-F piston pumps for push‑through filtration and foaming media
• Compliance: Designed for USP / Ph. Eur. harmonized requirements; supports 21 CFR Part 11 via q-doc®
• Verification: Gravimetric verification of vessel fill volumes
• Analytics: Supports offline sample collection for HPLC / UPLC analysis