Semi-automatic dissolution tester ATS Xtend™ Offline

for the pharmaceutical industryfor tabletsfor capsules

Overview
The ATS Xtend™ Offline is a semi-automated dissolution sampling system that withdraws, filters and collects samples for offline analysis. It supports simultaneous sampling from 6–8 vessels and collects into glass tubes, capped LC vials or HPLC/UPLC wellplates. The system standardizes sampling position, withdrawal force, volume, timing and filtration to improve repeatability and comparability of dissolution data.

Benefits

• Reproducible sampling: consistent withdrawal positions and standardized procedures reduce variability.
• Offline collection: compatible with tube, capped LC vial and wellplate workflows for HPLC/UPLC analysis.
• Flexible methods: schedule multiple timepoints and automatically replace withdrawn volumes.
• Fast sampling: piston pump enables timepoint intervals under 1 minute.
• Modified‑release support: automated filter changes at defined timepoints for DR/MR protocols.
• Fine filtration: supports filtration down to 0.2 μm for offline analysis when used with the CP piston pump.
• Flexible lab workflow: enables offline analysis without dedicating the dissolution tester to an analyzer.

Automation
The automated workflow performs simultaneous sampling, filtration and transfer to collection racks or vials. A multi-purpose media selector enables one‑touch sample line cleaning and automated volume replacement or controlled media/pH changes. Video monitoring and automatic temperature protocols support documentation and process control.

Highlights

• Standardized sampling parameters for improved data quality and comparability.
• Multi-purpose media selector for automated tube flushing and media handling.
• Effective filtration using tip/disc/syringe filters and the CP piston pump capable of pushing through filters down to 0.2 μm and handling foaming media.
• User interface EasyTouch™ for method selection and start; role‑based access for method modification.
• CenterView™ video monitoring to record vessel behavior and document deviations.

Modules (examples)

• AT dissolution tester (Xtend™ dissolution bath for sampling & monitoring).
• CP piston pump (piston pump for fine filtration and foaming media handling).
• SAM-SR sample manager (collects samples in tubes, capped LC vials or wellplates for offline analysis).
• FS filter station (automated syringe filter change for multi‑timepoint DR/MR methods).
• SP syringe pump (compact pump mounted on SAM collector).
• q-doc® and WinSOTAX®plus (data management and dissolution software with compliance features).
• MPS media station (mobile media preparation: heat, degas and dispense).
• CenterView™ (individual vessel video monitoring).

Options & Accessories

• Automated filter station for syringe filter changes during methods.
• Syringe pump modules and compact pumping options for space‑saving installations.
• Data management software packages with 21 CFR Part 11 capabilities.
• Spare parts and accessory kits for USP dissolution systems.

Technical specifications

• Sampling capacity: simultaneous sampling from 6–8 vessels.
• Collection formats: glass tubes, capped LC vials, HPLC/UPLC wellplates.
• Sampling repeatability: standardized position, withdrawal force, timing and volumes.
• Timepoint speed: intervals under 1 minute achievable with piston pump.
• Filtration capability: supports tip, disc and syringe filters; down to 0.2 μm with CP piston pump.
• Modified‑release support: automated filter changes at defined timepoints for DR/MR methods.
• Media handling: multi‑purpose media selector for one‑touch line cleaning and automated volume/media replacement or pH changes.
• User interface: EasyTouch™ for method selection and secure role‑based access.
• Monitoring: CenterView™ video monitoring and automatic temperature protocol (AutoLift™) support.
• Integration: compatible with q-doc® and WinSOTAX®plus for method sharing and compliant data handling.