Automatic dissolution tester ATF Xtend™ UV Online

fully-automaticfor the pharmaceutical industryfor tablets

Product overview
The ATF Xtend™ UV Online is a fully automated dissolution tester that delivers real-time UV-Vis results and consolidates protocolled test conditions and analytical data into a single dissolution report. It automates sequences from media preparation, degassing and vessel filling through sampling, analysis and clean-in-place, enabling unattended consecutive runs.

Key benefits

• 100% IMMEDIATE - Dissolution results generated in real time with integrated UV-Vis analysis.
• 100% AUTOMATED - Multiple dissolution tests run in unattended sequences from vessel filling to self-cleaning.
• 100% TRACEABLE - Every time point and event is programmed and recorded, including media preparation, wavelengths, standards, pH changes and cleaning routines.
• MEDIA - Repeatable media preparation with degassing, integrated vessel filling, and automated pH change.
• TEST - Automatic execution of entire series of dissolution runs under identical conditions.
• CLEAN - Clean-in-place routines with automated spray/power washing preparing the system for the next run.
• ANALYZE - Seamless integration of double-beam or diode-array UV-Vis spectrophotometers for immediate sample analysis.

Highlights

• Integrated MP-F media station: prepares, heats, degasses (vacuum deaeration at temperature) and power-washes the media tank; suitable for foaming media with surfactants.
• Automated vessel filling dispenses media down the vessel wall to avoid reaeration and includes gravimetric verification of delivered volumes.
• Immediate analysis: integrated UV-Vis spectrophotometers measure each vessel at one or multiple timepoints for IR, DR or MR methods.
• Fully automated sampling and filtration with integrated filter-exchange station for consecutive runs.
• CenterView™ video monitoring for individual vessel observation throughout the test, increasing repeatability and traceability.
• Self-centering vessels with quick-lock system for consistent alignment and compliance-by-design.
• Consolidated data management with q-doc® software offering built-in data integrity and regulatory compliance (e.g., 21 CFR Part 11 support).

Modules & options

• AT-F bath: integrated module with vessel filling, sampling and cleaning functions.
• MP-F media station: integrated station to prepare, heat and degas dissolution media.
• CP-F piston pump: sampling pump capable of pushing through filters and handling foaming media.
• FS-F filter station: automatic filter exchange for multiple test runs.
• CS-F cleaning station: automated emptying and spray cleaning of vessels (CIP).
• Specord® UV-Vis: double-beam spectrophotometer for realtime dissolution data.
• UV7 UV-Vis (option): compact diode array spectrophotometer for UV Online.
• CenterView™ (option): video monitoring of the dissolution process in each vessel.
• RS robotic station (option): automated USP 1 basket exchange and USP 2 sinker retrieval.
• q-doc® software: centralized data management for methods, results and users with compliance features.

Analytical & automation workflow

• Automated workflow: media preparation (recipes, degassing), vessel filling, gravimetric volume confirmation, automated sampling & filtration, inline or offline UV-Vis analysis, automated cleaning and next-run initialization.
• Analytics integration: supports double-beam and diode-array UV-Vis systems for immediate concentration readings; multiple timepoint acquisition per vessel.
• Traceability: protocolled records of media recipes, wavelengths, standards, pH adjustments, sampling events, cleaning cycles and video logs.

Technical specifications

• Model name: ATF Xtend™ UV Online.
• Manufacturer / Brand: SOTAX.
• Automation: fully automated sequence from media preparation to cleaning (unattended runs).
• Analysis: integrated UV-Vis spectrophotometry (double-beam or diode-array) for realtime dissolution data.
• Media handling: MP-F media station with heating, vacuum degassing and power-wash cleaning routines; supports foaming media.
• Filling: automated vessel filling down the vessel wall to avoid reaeration; gravimetric verification of volumes.
• Sampling & filtration: CP-F piston pump for robust sampling; FS-F filter station for automatic filter exchange.
• Cleaning: CS-F cleaning station for spray cleaning and emptying; customizable CIP routines.
• Monitoring: CenterView™ video monitoring for each vessel; in-vessel volume monitoring available.
• Robotics: RS robotic station for automated basket exchange and sinker handling (option).
• Data management: q-doc® software for method/result consolidation and regulatory compliance (21 CFR part 11 features).
• Reporting: automatic consolidation of protocolled test conditions and analytical results into single dissolution reports.