Automated sample preparation system Bruker Automation Package

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Overview
Automated, parallel library synthesis and high-throughput reaction screening with integrated online benchtop NMR. The FLEX ISYNTH platform (Chemspeed) is a flexible, modular automated solution enabling fast, broad exploration of reaction, reagent and molecule space. The system supports fully automated reaction set-up, multistep synthesis, work-up, purification, analytical integration and transfer of products to storage vials.

Workflow (example steps)

• Inertization
• Gravimetric dispensing (solids)
• Volumetric dispensing (liquids)
• Heating while shaking
• Sampling (direct injection or into NMR tube)
• Work-up (filtration, liquid/liquid extraction, SPE)
• Online/offline NMR analysis

Benefits

• Fully automated, integrated reaction preparation, multistep synthesis, work-up, analysis and output to storage for solid- and liquid-phase library synthesis and reaction screening
• Disposable multifunctional, high-precision glass reactor arrays; scalable reaction volumes from μL to mL
• Screwless, self-sealing glass reactors; mixing by shaking (up to 1'700 rpm), heating (up to 150°C) and cooling (down to -20°C); reflux, vacuum and evaporation capabilities
• Support for conventional, microwave-assisted, photochemistry and reactive gas modalities
• Gravimetric solid handling from μg to g and gravimetric/volumetric liquid handling from mg to g and μL to mL
• Integrated sampling and analytics including benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR/MIR and DLS
• Ventilated hood for safe, conditioned operation
• AUTOSUITE software: drag & drop experiment design, Python device support, LIMS/ELN integrations, data analysis and AI/ML closed loop
• Proprietary robotic tool exchange for flexible automation workflows

Technical specifications

• Product platform: FLEX ISYNTH (Chemspeed)
• Automation: fully automated reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage
• Reaction modalities: conventional, microwave-assisted, photochemistry, reactive gas
• Reactor format: disposable high-precision glass reactor arrays; screwless, self-sealing
• Reaction scale: μL to mL
• Mixing: shaking up to approx. 1'700 rpm
• Temperature range: heating to 150°C; cooling to -20°C
• Throughput: parallel reactions (examples 24 / 48 / 96 per run)
• Solid handling: gravimetric, range μg → g
• Liquid handling: gravimetric and volumetric, ranges mg → g and μL → mL
• Work-up capabilities: filtration, liquid/liquid extraction, SPE, crystallization, drying, evaporation, reflux, vacuum
• Safety/installation: ventilated hood for safe, conditioned operation
• Robotics: proprietary robotic tool exchange
• Software: AUTOSUITE (drag & drop experiment automation; Python custom device support; LIMS/ELN and AI/ML integrations)
• Analytics integration: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR/MIR, DLS measurement cell
• Online NMR specifics: example 80 MHz Fourier RxnLite; sample injection port; flow cell or 5 mm tube support; 1D/2D spectra; nuclei supported H / F / C / P / Si / B; permanent magnet technology (no cryogens required)