Synthesis platform ISYNTH SPEEDCHEM

Overview This automated solution enables parallel high-throughput library synthesis in 96-well microtiter plates using disposable glass vials/reactors under accelerating superheated conditions (van't Hoff principle). The system leverages elevated temperature and autogenous pressure to shorten reaction times and often improve selectivity across small-molecule, polymer, porous-materials and cathode-materials workflows.

Workflow

• Add catalyst / solid reagent
• Add solvent / liquid reagents
• Transfer MTP to pressure block
• Shake, heat (van't Hoff, SPEEDCHEM)
• Transfer MTP to tray
• Work-up (e.g. filtration, sampling)

Key features and capabilities

• High-throughput library synthesis in disposable glass vials/reactors compatible with 96‑well MTP format
• Operation under accelerating superheated conditions to increase reaction rates (van't Hoff principle)
• Combination of elevated temperature and autogenous pressure for faster reactions and often higher selectivity
• 4-needle head for volumetric liquid handling and sampling
• Gravimetric solid dispensing supporting multiple vial/plate/reactor formats
• Robotic powder dispensing/dosing tool for integration in multi-step workflows
• Reagent preparation (liquids and solids), multi-step synthesis, work-up, purification, analysis and product transfer to storage
• Disposable glass reactors to simplify handling and contamination control
• Ventilated hood and trolley options for safety and handling
• Optimized compact footprint (approx. 3 x 3 ft / 90 x 90 cm) balancing capacity and cost-efficiency
• Increased reagent solubility and milder effective conditions reducing side reactions and improving yields
• Lower energy usage compared to some conventional workflows
• AUTOSUITE software for drag & drop experiment design, execution and data analysis
• Interfaces to DOE, ML, AI, LIMS, ELN and ERP systems for integration and advanced data workflows

Benefits

• Substantially faster reaction rates (example: ~40°C above boiling point can yield ~16x faster reactions)
• Higher chemical yields and fewer side reactions
• Flexible, exchangeable robotic tools to accommodate multiple workflows
• End-to-end automation from reagent dosing through work-up and transfer to storage

Technical specifications

• Commercial name / model: FLEX SPEEDCHEM
• Format compatibility: 96-well MTP format with disposable glass vials/reactors
• Liquid handling: 4-needle head for volumetric dispensing and sampling
• Solid handling: Gravimetric solid dispensing and powder dosing robotic tool
• Thermal/pressure mode: Accelerating superheated conditions using elevated temperature and autogenous pressure (van't Hoff / SPEEDCHEM heating)
• Typical footprint: approx. 3 x 3 ft (90 x 90 cm)
• Software: AUTOSUITE (drag & drop experiment design), integration with ARKSUITE for orchestration
• Integration: Interfaces to DOE, ML, AI, LIMS, ELN, ERP
• Safety: Ventilated hood and trolley options
• Applications: Small-molecule, polymer, porous materials, cathode materials synthesis, multi-step synthesis and automated work-up