Robotic sample preparation system Bruker Automation Package

fully automatedlaboratoryfor the pharmaceutical industry

Overview
Automated, parallel materials library synthesis (e.g. MOFs, perovskites) and crystallization optimization (e.g. active ingredients) with integrated online benchtop XRD. Chemspeed’s FLEX ISYNTH is a modular, fully automated workstation enabling high-throughput exploration of reaction, reagent and materials space, supporting multistep synthesis workflows from reagent setup to storage.

Benefits

• Fully automated workflow: reaction preparation, multistep synthesis, work-up, purification, analysis and transfer to storage for solids and liquids.
• Disposable high-precision glass reactor arrays for reaction scales from μL to mL; screwless, self-sealing design.
• Controlled mixing (up to ~1'700 rpm), heating (up to 150°C), cooling (-20°C), reflux, vacuum, inert atmosphere; supports evaporation, L/L extraction, filtration, SPE, crystallization and drying.
• Gravimetric solid handling (μg–g) and liquid handling (mg–g / μL–mL); chemistry-proven features such as pH control and heated needle extension.
• High parallel throughput (e.g. 24/48/96 reactions per run) with proprietary robotic tool exchange and automated sample handover.
• Integrated analytics: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV‑VIS, NIR/MIR, DLS and integrated online benchtop XRD (e.g. Bruker D6 Phaser, Malvern Aeris) with sample handover and software/hardware integration.
• Ventilated hood for safe, conditioned operation.
• AUTOSUITE software for drag & drop experiment design; interfaces to LIMS/ELN, data analysis and AI/ML closed-loop workflows; ARKSUITE orchestration for lab-wide workflows.

Solution summary
FLEX ISYNTH unlocks broad chemical and materials spaces by enabling high-throughput, parallelized synthesis with integrated online benchtop XRD for closed-loop experimentation and data-driven optimization. The platform automates sampling and integrates multiple benchtop analytical instruments to accelerate materials discovery and crystallization screening.

Technical specifications

• System: FLEX ISYNTH — modular, fully automated workstation.
• Reaction formats: Disposable multifunctional glass reactor arrays; reaction scales μL–mL.
• Mixing: Shaking up to ~1'700 rpm.
• Temperature control: Heating to 150°C; cooling to -20°C; supports reflux, vacuum, inertization.
• Supported operations: Evaporation, L/L extraction, filtration, SPE, crystallization, drying.
• Handling: Gravimetric solids μg–g; liquids mg–g / μL–mL.
• Throughput: Parallel reactions (e.g. 24/48/96 per run).
• Robotics: Proprietary tool exchange; automated sample handover.
• Integrated analytics: Benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV‑VIS, NIR/MIR, DLS; integrated online benchtop XRD (e.g. Bruker D6 Phaser, Malvern Aeris) with sample handover and full software/hardware integration.
• Software: AUTOSUITE; interfaces to LIMS/ELN, data analysis, AI/ML; ARKSUITE orchestration.
• Safety: Ventilated hood for conditioned operation.