Microwave synthesis platform ISYNTH NMR

Overview
ISYNTH, combining Chemspeed patented overhead gravimetric dispensing/dosing with modular synthesis reactor formats and intuitive software, enables accelerated, standardized and digitized library synthesis and reaction screening workflows. The system supports automated high-throughput synthesis and reaction screening with integrated online benchtop NMR for real-time characterization and data-driven experiment control.

Product details
Chemspeed ISYNTH is a fully automated, modular solution that performs reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage. Deck modularity accommodates conventional, microwave-assisted, photochemistry and reactive gas reactor formats. The platform is suitable for parallel reaction arrays and a wide range of reaction types including C–C and C–N couplings, organometallic reactions, alkylations, Diels–Alder and transfer hydrogenations.

Workflow (ISYNTH with integrated online / offline NMR)
The workflow includes inertization, gravimetric solid dispensing, volumetric liquid dispensing, heating with shaking, sampling (direct injection or into NMR vial), work-up operations (filtration, liquid/liquid extraction, SPE) and online/offline NMR analysis. Integrated sampling and analytics feed experiment control and software-driven data analysis.

Benefits

• Fully automated end-to-end reaction preparation, synthesis, work-up, analysis and transfer to storage vials for solid- and liquid-phase libraries and reaction screening.
• Disposable multi-functional, high-precision glass reactor arrays for scales from μL to mL.
• Screwless self-sealing glass reactors; mixing by shaking up to 1,700 rpm; heating to 150°C; cooling to −20°C / −70°C depending on configuration; reflux, vacuum and inertization; evaporation, L/L extraction, filtration, SPE, crystallization and drying.
• Proprietary robotic tool exchange for flexible automation.
• Gravimetric solid handling from μg to g and gravimetric liquid handling from mg to g; volumetric liquid dispensing from μL to mL.
• Chemistry-proven liquid handling features such as pH control, filtration and heated needle extension.
• High parallel throughput (examples: 24 / 48 / 96 and beyond).
• Integrated sampling and analytics including benchtop online NMR (e.g. 80 MHz Fourier RxnLite or similar), HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR/MIR and DLS measurement cell; online flow-cell or offline 5 mm sample tube acquisition; supports 1D/2D spectra and nuclei H / F / C / P / Si / B.
• AUTOSUITE software for drag & drop experiment design and execution with options for custom Python device integration, LIMS/ELN connectivity and AI/ML closed-loop workflows. ARKSUITE available to orchestrate multi-system lab workflows.
• Ventilated, conditioned hood for sensitive low-temperature chemistry; optional integration within customized glove-box.

Technical specifications

• Denomination: ISYNTH
• Automated capabilities: reaction preparation, multistep synthesis, work-up, purification, analysis, product transfer to storage
• Dispensing technologies: patented overhead gravimetric dispensing/dosing for solids and liquids; volumetric liquid dispensing
• Reactor formats: conventional, microwave-assisted, photochemistry, reactive gas
• Reactor hardware: disposable high-precision glass reactor arrays; screwless self-sealing design
• Mixing: shaking up to ~1,700 rpm
• Temperature control: heating up to 150°C; cooling down to −20°C and −70°C (depending on configuration)
• Pressure/environment: inertization, vacuum, reflux capabilities
• Scale: reaction scales from microliter (μL) to milliliter (mL)
• Solid handling: gravimetric from micrograms (μg) to grams (g)
• Liquid handling: gravimetric from milligrams (mg) to grams (g) and volumetric from μL to mL
• Analytics: integrated online benchtop NMR (examples: 80 MHz Fourier RxnLite or similar), HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR/MIR, DLS; online data acquisition via flow cell or offline via standard 5 mm sample tubes; supports 1D and 2D spectra and multiple nuclei (H / F / C / P / Si / B)
• Software: AUTOSUITE (experiment design & execution, data analysis, device integration) and ARKSUITE (lab orchestration, workflows, inventory, messaging)
• Throughput: supports parallel reaction arrays (e.g. 24/48/96 wells and beyond)
• Robotics: proprietary robotic tool exchange for flexible automation