Microwave synthesis platform ISYNTH AI

Overview
Automated parallel library synthesis and reaction screening using disposable glass reactors (including photochemistry). Molecular diversity and discovery workflows for medicinal and chemical research enabled by Chemspeed high-throughput solutions: disposable glass vials, reusable double-jacket reactors, microwave reactors and photochemical glass reactors. ISYNTH AI is a modular, fully automated platform designed to explore reaction, reagent and molecule space with flexible deck configurations and integrated analytics.

Workflow — ISYNTH AI
Typical automated workflow steps and tool capabilities include:

• Inertization
• Gravimetric solid dispensing (μg to g)
• Volumetric liquid dispensing (μL to mL) and gravimetric liquid dosing (mg to g)
• Heating with high-speed shaking
• Optional sampling (direct injection or HPLC vial)
• Work-up operations (filtration, liquid/liquid extraction, SPE)
• Sample collection and automated transfer to storage vials

Benefits

• Complete automation of reaction preparation, multistep synthesis, work-up, analysis and product transfer for solid- and liquid-phase library synthesis and reaction screening.
• Disposable high-precision glass reactor arrays with screwless, self-sealing opening/closing; reaction scales from μL to mL.
• Reactor capabilities: high-rpm shaking, heating to ~150°C, cooling to approx. -20°C and -70°C, reflux, vacuum and inert atmosphere.
• Integrated modules for microwave and photochemical processing and reusable double-jacket reactors.
• Proprietary robotic tool exchange for modular automation and high-throughput formats (e.g. 24 / 48 / 96 parallel reactions).
• Advanced liquid handling features (pH handling, filtration, heated needle extension) and gravimetric solid handling.
• Optional ventilated conditioned hood or glove-box integration for sensitive chemistries.
• Sampling and analytics integration: benchtop online NMR, HPLC-MS, UPLC-MS, GC-MS, UV-VIS, NIR/MIR and DLS measurement cells.
• AUTOSUITE for drag & drop experiment design and execution; Python device support and connectivity to LIMS, ELN, data analysis and AI/ML closed-loop workflows; ARKSUITE for cross-system orchestration.
• Optional integrated benchtop NMR (e.g. 80 MHz RxnLite) with flow or 5 mm tube injection supporting 1D/2D spectra and advanced profiling.

Technical specifications

• Workflow type: automated parallel library synthesis and reaction screening (conventional, microwave-assisted, photochemical, reactive gas capable).
• Typical throughput: scalable parallel arrays supporting 24 / 48 / 96 (and higher) reactions per run.
• Reactor types: disposable glass vial arrays, reusable double-jacket reactors, microwave reactors, photochemical glass reactors.
• Mixing: high-speed shaking (high rpm capability for glass reactor arrays).
• Temperature control: heating up to ~150°C; cooling options to approx. -20°C and -70°C.
• Atmosphere control: inertization, vacuum, reflux.
• Solid handling: gravimetric dispensing from μg to g.
• Liquid handling: gravimetric from mg to g; volumetric from μL to mL; chemistry-proven features such as pH control, filtration, heated needle extension.
• Work-up: filtration, liquid/liquid extraction, SPE, crystallization, evaporation, drying.
• Sampling & analytics: optional sampling to HPLC vials or direct injection; support for benchtop online NMR, HPLC-MS, UPLC-MS, GC-MS, UV-VIS, NIR/MIR, DLS measurement cells.
• Software: AUTOSUITE for experiment design & execution; ARKSUITE for system orchestration, workflows, inventory and data management.
• Optional hardware: ventilated conditioned hood and glove-box integration options.