Low density lipoprotems (LDL) are synthesized in the liver by the action of various lipolytic enzymes on triglycéride rich very-low- density lipoproteins (VLDLs). SpEcifie LDL receptors exist to facililate the Elimination of LDL from plasma by liver parenchymal cells.lt has been shown that most of the cholestérol stored in atherosclerotic plaques originates from LDL. For this reason the LDL-Cholesterol concentration is considered to be the most important clinical predictor, of ail single parameters. with respect to coronary atherosclerosis.
Accurate measurement of LDL-Cholesterol is of vital importance in thErapies which focus on lipid rEduction to prevent atherosclerosis or reduce its progress and to avoid plaque rupture.In this diagnostic test kit an Elimination method for the measurement of LDL-Cholesterol. without sample pretreatment. is presented which correlates well with prEcipitation and ultracentrifugation methods
Linearity
The method ts linear upto 18 mmol/L.
Sample above linearity limit should be diluted with£ 0.9% Na Cl Mulbply the resuLT by dilution factor.
Sensitivity
The sensitivity of the LDL-C is 0.03mmol/L