Vial filling and sealing machine STERIFILL Series

for ampoulesfor the pharmaceutical industryautomatic

Overview
STERIFILL is a compact, ergonomic linear ampoule filling and sealing machine designed for pharmaceutical sterile production. It handles opened ampoules (type B and C) and closed ampoules (type D) and can be configured with up to 10 dosing pumps to meet medium-to-high throughput requirements. The machine geometry supports unidirectional airflow and easy cleaning, making it suitable for integration with controlled-environment equipment such as LAF hoods, RABS and isolators.

Key functionality

• No ampoule – no fill system to prevent product loss and ensure process integrity.
• Positive transport system for stable product handling during filling and sealing.
• Optional CIP/SIP integration enabling programmable automatic cleaning/sterilization cycles without component removal.
• Standard safety features for gas/oxygen circuits: safety valves, exhaust aspiration, reinforced PTFE hoses and dedicated fastenings.
• Siemens touch screen HMI for intuitive operator control and process monitoring.
• Easy access design for direct maintenance and cleaning; tool-free, fast size changeover.

Sterifill COMBI version
The COMBI variant retains the same design and technical features while allowing alternating processing of ampoules and vials with a rapid, tool-free changeover procedure, extending the machine's versatility for mixed production needs.

Machine highlights

• Efficient, loss-minimizing filling: no ampoule – no fill system.
• Reliable handling: positive transport system for consistent indexing.
• Automated hygiene cycles: CIP/SIP programmable without disassembly.
• Pharmaceutical-grade safety equipment as standard for gas/oxygen lines.
• User-friendly control: Siemens HMI.
• Designed for accessibility to simplify maintenance and cleaning.
• Fast, tool-free format changeover to reduce downtime.

Technical data (table)
TECHNICAL DATA STERIFILL
Model | STERIFILL B4 | STERIFILL B4 COMBI | STERIFILL B6 | STERIFILL B6 COMBI | STERIFILL B8 | STERIFILL B8 COMBI | STERIFILL B10 | STERIFILL B10 COMBI
Output – ampoules (pieces/minute) | 200 | 200 | 300 | 300 | 400 | 400 | 500 | 500
Output – vials (pieces/minute) | – | 150 | – | 225 | – | 300 | – | 375
Filling pumps | 4 | 4 | 6 | 6 | 8 | 8 | 10 | 10
Filling range (ml) | 0.5 – 20 | 0.5 – 50 | 0.5 – 20 | 0.5 – 50 | 0.5 – 20 | 0.5 – 50 | 0.5 – 20 | 0.5 – 50
Ampoule diameter (mm) | 10.75 – 22.5 (all models)
Vial diameter (mm) | – | 16 – 42.5 | – | 16 – 42.5 | – | 16 – 42.5 | – | 16 – 42.5
Standard voltage | 400 V – 50 Hz (all models)
Installed power (kW) | 18 | 20 | 18 | 20 | 18 | 20 | 18 | 20
Weight (kg) | 1800 | 2000 | 1900 | 2100 | 2000 | 2200 | 2100 | 2300
Machine dimensions (mm) (A / B / C) | B4 series: A – 3300 | B – 1150 | C – 2020; B4 COMBI: A – 3600 | B – 1700 | C – 2020; B6 series: A – 3300 | B – 1150 | C – 2020; B6 COMBI: A – 3600 | B – 1700 | C – 2020; B8 series: A – 3300 | B – 1150 | C – 2020; B8 COMBI: A – 3600 | B – 1700 | C – 2020; B10 series: A – 3650 | B – 1150 | C – 2020; B10 COMBI: A – 3950 | B – 1700 | C – 2020

Characteristics / technical specifications

• Product family: Linear ampoule filling and sealing machine (STERIFILL series).
• Supported processing types: Opened ampoules (type B, C) and closed ampoules (type D); COMBI versions support alternating ampoules and vials.
• Maximum dosing pumps: up to 10 pumps depending on model.
• Filling range: 0.5 – 20 ml standard; up to 50 ml on COMBI variants.
• Throughput: ampoules 200–500 pcs/min depending on model; vials on COMBI models 150–375 pcs/min depending on model.
• Materials & safety: gas/oxygen safety valves, exhaust aspiration, reinforced PTFE hoses and dedicated fastening for gas/oxygen circuits.
• Cleaning: CIP/SIP optional for automatic cycles without disassembly.
• Drive: fully brushless motor driven for precision and gentle motion.
• Control: Siemens touch screen HMI.
• Installation: suitable for wall installation; available standalone or for integration into processing lines (compatible with LAF hoods, RABS, isolators).
• Electrical: standard voltage 400 V – 50 Hz.
• Installed power: typically 18–20 kW depending on model.
• Weights and dimensions: model-dependent (weights 1800–2300 kg; dimensions A/B/C vary by model as listed).