Dissolution autosampler ATF Xtend™

for HPLCsamplingfor liquid chromatography

Overview
Fully automated system for direct injection of collected dissolution samples into HPLC / UPLC systems. Designed for end-to-end unattended dissolution testing workflows including media preparation, automated sampling, filtration, collection, direct LC injection and validated cleaning procedures.

Benefits

• 100% DIRECT - Injection of samples from multiple dissolution runs directly into HPLC / UPLC systems.
• 100% AUTOMATED - Run a series of unattended tests overnight or over the weekend.
• 100% TRACEABLE - Program every time point and event of the dissolution profile including media preparation, standards, pH changes and cleaning.
• MEDIA - Fully automated media preparation, degassing and vessel filling with gravimetric confirmation of delivered volumes.
• TEST - Maximum repeatability with automated sampling, filtration, collection and direct injection.
• CLEAN - Validated cleaning procedures automatically executed between dissolution runs.
• FINE FILTRATION - Push-through filtration down to 0.2 microns for trouble-free LC injection.

Automation
The system supports fully automated media preparation (heating, degassing), gravimetric volume confirmation, automated sampling and filtration, automated vial/wellplate collection and sequential direct injection into LC systems. High-precision piston pump heads enable short sampling intervals and robust handling of foaming media and fine porosity filters.

Highlights

• Direct Injection. Filtration down to 0.2 μm enables direct LC injection and minimizes manual sample handling and transit time from collection to analysis.
• 100% Unattended. True end-to-end automation allowing multiple runs with automated cleaning between tests and integrated medium handling.
• Faster. Stronger. Better. High-precision piston pumps provide short sampling intervals and reliable filtration without syringe-pump limitations.
• Traceable Repeatability. Integrated protocolling, in-vessel volume monitoring and CenterView™ video monitoring ensure repeatable, fully traceable test execution.
• Compliance by Design. Self-centering vessels, quick-lock system and built-in data management compliant with 21 CFR part 11; AutoCompliance™ and q-doc® software for method and data management.

Modules & Options

• AT-F bath – Integrated module with vessel filling, sampling and cleaning functions.
• MP-F media station – Integrated module to prepare, heat and degas dissolution media.
• CP-F piston pump – Fast, powerful pump heads to push through filters and handle foaming media.
• CS-F cleaning station – Integrated module for spray cleaning and emptying of vessels.
• SAM S sample manager (LC) – Collect samples offline in tubes, capped LC vials and wellplates.
• HPLC / UPLC – Direct injection analytical configuration for sample analysis.
• CenterView™ – Individual video monitoring of each dissolution vessel.
• q-doc® software – Centralized data management with built-in compliance features (21 CFR part 11).

Downloads (document titles available on the product page)

• ATF Xtend™ – Brochure (PDF)
• ATS Xtend™ LC On-/Offline – Flyer (PDF)
• Global Services – Brochure (PDF)

Caractéristiques / spécifications techniques

• Direct injection into HPLC / UPLC; eliminates manual vial handling.
• Push-through filtration capability down to 0.2 microns.
• Fully automated media preparation: heating, degassing and vessel filling with gravimetric confirmation.
• High-precision piston pump heads for short sampling intervals and reliable filtration through fine porosity filters.
• Automated sampling, filtration, collection (tubes, capped LC vials, wellplates) and sequential injection.
• Validated automatic cleaning procedures executed between runs.
• Integrated in-vessel volume monitoring and CenterView™ video monitoring for traceability.
• Self-centering vessels with quick-lock system for easy and repeatable positioning.
• Designed for compliance: q-doc® data management, AutoCompliance™ and 21 CFR part 11 capabilities.
• Modular architecture: AT-F bath, MP-F media station, CP-F piston pump, CS-F cleaning station, SAM S sample manager, and LC/UPLC integration.