Flash chromatography system Isolera™ One

for researchfor drug discoveryultraviolet

Overview
Isolera™ One is a compact flash chromatography system for routine purification in drug discovery and research laboratories. It recommends optimal cartridges and solvent gradients from sample and TLC data to reduce solvent consumption and streamline workflows. The system supports internal and external real‑time detectors for accurate fraction collection across multiple configurations.

Main benefits

• Designed for routine throughput (~1–5 purifications per day).
• Wide flow range to support various column sizes and scales.
• Reduces solvent use by suggesting optimal cartridges and gradients based on sample and TLC information.
• Real‑time detection options (internal UV or external detectors) for precise fraction collection.
• Compatible with Biotage® Sfär prepacked columns for high-resolution separations.

Notable features

• Flow rate range: 1–200 mL/min.
• Max pressure: up to 10 bar (145 psi).
• Column capacity: up to ~950 g (dependent on cartridge).
• Single column channel (single‑channel operation).
• On-board computer with 10.4" capacitive touchscreen for control and method entry.
• Detector options: variable wavelength internal detector (200–400 nm) or UV‑VIS internal detector (200–800 nm); external detector support available.
• Supports extended and single collection bed configurations.

Applications

• Purification of synthesis mixtures, natural product extracts and organic compounds from milligram to multi‑gram scale.
• Lab‑scale flash chromatography and routine purification workflows in drug discovery and research labs.

Compatible accessories & add-ons

• Compatible with Biotage® Sfär and related prepacked columns.
• Available configurations include extended and single collection beds and detector choices (200–400 nm or 200–800 nm UV‑VIS).

Technical specifications

• Flow rate range: 1–200 mL/min.
• Pressure: 145 psi (10 bar) max.
• Column channels: One.
• Interface: On‑board computer with 10.4" capacitive touchscreen.
• Supported rack types: 13 x 100 mm; 16 x 100 mm; 16 x 150 mm; 18 x 150 mm; 25 x 150 mm; 120 mL; 240 mL; 480 mL.
• Column capacity: up to ~950 g (application dependent).
• Recommended throughput: ~1–5 purifications/day.
• Location: laboratory fume hood capable of handling solvent leakage and preventing flammable vapor build‑up.
• Operating ambient temperature: 15–32 °C (59–90 °F).
• Storage/transport temperature: -25–60 °C (-13–140 °F).
• Humidity: 20–95% RH (non‑condensing).
• Altitude: up to 2000 m above sea level.
• Pollution degree: install in pollution degree 2 environment per EN 60664‑1.
• Electrical supply: 100–240 VAC, 50/60 Hz, 4.0 A.
• Weight: 30–35 kg (66–77 lbs) depending on configuration.
• Dimensions (W x D): 355 mm x 497 mm; add 178 mm with extended bed; Height: 596 mm (excluding secondary solvent containment).
• Ports: Ethernet, 4 × USB, 2 × D‑Sub 9‑pin, AUX.
• Data entry: touchscreen or USB connection for mouse/keyboard.
• Certifications: CE and cTÜVus.
• Internal detector wavelength options: variable 200–400 nm or UV‑VIS 200–800 nm; external detector support possible.