Flash chromatography system Isolera™ LS 150

automated flashfor pharmaceutical laboratoriesfor large-scale production

Overview
A fully automated flash chromatography system designed to bridge laboratory development and production-scale purification. The Isolera™ LS 150 provides scalable flash purification with high flow capacity and compatibility with large prepacked columns to support efficient process scale-up.

Key capabilities

• Fully automated flash chromatography for development and production workflows
• Supports prepacked columns from 50 g to 8 kg for high-throughput scale-up
• High flow performance up to 500 mL/min to enable transfer to large-column formats
• Intuitive large touchscreen and advanced software with automated fraction collection, gradient equilibration, 3D sample peak visualization, and improved method reproducibility
• Flexible method development and scale-up: conversion to step and isocratic gradients, workflows scalable from TLC to flash columns

Scale and hardware highlights

• Flow capacity up to 500 mL/min and support for columns up to 8 kg capacity
• Compatibility with a wide range of prepacked column sizes to ensure safe and efficient scale-up

Software and collection features

• Advanced touchscreen interface with access to automated workflows
• Automated fraction collection modes and fractionation strategies to improve yield and reproducibility

Technical specifications

• Weight: 42–46 kg (93–102 lbs) depending on system configuration
• Dimensions: Isolera™ LS 150: 577 x 497 x 596 mm (22.7" x 19.6" x 23.5"); Flash 150 column: 56 x 56 x 106 mm (22" x 22" x 42")
• Flow rate range: 50–500 mL/min
• Solvent delivery: Two constant-volume (11 mL) electric HPFC pumps
• Fraction collection modes: Volume, threshold, threshold with volume, low slope, medium slope
• Collection vessels: Test tubes (13, 16, 18, and 25 mm) and bottles (120 mL, 240 mL, 480 mL)
• UV detection: 200–800 nm for Isolera™ LS 150 system; upgrade kit retrofit options include 200–400 nm or 200–800 nm
• UV collection modes: Single / dual / λ-All wavelengths (variable UV and UV-VIS)
• Power requirements: 100–240 VAC, 50/60 Hz, 4.0 A