Antibody Bcl-2

monoclonal antibodytissueimmunohistochemistry

Antigen Background
Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor of apoptosis. For this reason, Bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway.

In 90% of follicular lymphomas a translocation occurs which juxtaposes the Bcl-2 gene at 18q21, to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and Bcl-2 over-expression can be demonstrated immunohistochemically in the vast majority of follicular lymphomas.

Disclaimer
Bcl-2 Oncoprotein is recommended for the detection of specific antigens of interest in normal and neoplastic tissues, as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Products / Available configurations

• BCL-2-L-CE — 1ml NCL-L-bcl-2
  • Clone: BCL-2/100/D5
  • Pathology Menu: Hematopathology
  • Configuration: Liquid Concentrate
  • HD (High Definition): Yes
  • Use: P (HIER)
  • Source: Mono
  • Species: Mouse
  • Regulatory Status: In Vitro Diagnostic Use
  • Volume: 1ml
• PA0117 — 7ml Bcl-2 Bond RTU Primary
  • Clone: BCL-2/100/D5
  • Pathology Menu: Hematopathology
  • Configuration: BOND RTU
  • HD (High Definition): Yes
  • Use: P (HIER)
  • Source: Mono
  • Species: Mouse
  • Regulatory Status: In Vitro Diagnostic Use
  • Volume: 7ml
• BCL-2-L-U — 1ml NCL-L-bcl-2 (US configuration)
  • Clone: BCL-2/100/D5
  • Pathology Menu: Hematopathology
  • Configuration: Liquid Concentrate
  • HD (High Definition): Yes
  • Use: P (HIER)
  • Source: Mono
  • Species: Mouse
  • Regulatory Status: In Vitro Diagnostic Use
  • Volume: 1ml
• PA0117-U — 7ml Bcl-2 Bond RTU Primary (US configuration)
  • Clone: BCL-2/100/D5
  • Pathology Menu: Hematopathology
  • Configuration: BOND RTU
  • HD (High Definition): Yes
  • Use: P (HIER)
  • Source: Mono
  • Species: Mouse
  • Regulatory Status: In Vitro Diagnostic Use
  • Volume: 7ml

Replaces

• BCL-2
• BCL-2-486
• BCL-2-486-S
• BCL-2-486-U
• BCL-2-CE
• BCL-2-CE-S
• BCL-2-O
• BCL-2-R-7-CE
• BCL-2-S
• BCL-2-L

Characteristics / technical specifications

• Clone: BCL-2/100/D5
• Target pathology area: Hematopathology
• Intended use: Immunohistochemistry (P - HIER)
• Configurations available: Liquid Concentrate; BOND RTU (ready-to-use)
• HD (High Definition) compatible: Yes
• Source: Monoclonal antibody
• Host species: Mouse
• Regulatory status: In Vitro Diagnostic Use
• Available volumes: 1ml (concentrate); 7ml (BOND RTU)
• Available SKUs: BCL-2-L-CE, PA0117, BCL-2-L-U, PA0117-U