Antibody CD5

monoclonal antibodyimmunohistochemistryfor histopathology

Antigen Background
CD5 antigen is expressed on approximately 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, CD5 reactivity is primarily observed on T cells. CD5 is also expressed by many T-cell leukemias and lymphomas, by activated T cells and by a subset of B cells located mainly in the mantle zones of normal lymph nodes. CD5 expression is reported in T-cell acute lymphoblastic leukemia (T-ALL), some B-cell chronic lymphocytic leukemias (B-CLL) and in certain B- and T-cell lymphomas.

Image Caption
Human mantle cell lymphoma: immunohistochemical staining for CD5. Tumor cells show a strong membranous staining reaction. CD5: clone 4C7

Disclaimer
Recommended for the detection of target antigens in normal and neoplastic tissues as an adjunct to conventional histopathology using non-immunologic histochemical stains.

Available Product Configurations

• CD5-4C7-L-CE — 1ml NCL-L-CD5-4C7
• CD5-4C7-L — 1ml NCL-L-CD5-4C7
• PA0168 — 7ml CD5 Bond RTU Primary
• CD5-4C7-L-U — 1ml NCL-L-CD5-4C7 (US/Canada availability)
• PA0168-U — 7ml CD5 Bond RTU Primary (US/Canada/Australia availability)

Technical characteristics / specifications

• Clone: 4C7
• Pathology Menu: Hematopathology
• Primary Use: P (HIER)
• Source: Monoclonal
• Species: Mouse
• HD (High Definition): Yes
• Variants and regulatory/volume details:
  • CD5-4C7-L-CE — Configuration: Liquid Concentrate; Regulatory Status: In Vitro Diagnostic Use; Volume: 1ml
  • CD5-4C7-L — Configuration: Liquid Concentrate; Regulatory Status: Research Use Only; Volume: 1ml
  • PA0168 — Configuration: BOND RTU; Regulatory Status: In Vitro Diagnostic Use; Volume: 7ml
  • CD5-4C7-L-U — Configuration: Liquid Concentrate; Regulatory Status: In Vitro Diagnostic Use; Volume: 1ml (availability in Canada, Puerto Rico, Trinidad and Tobago, United States)
  • PA0168-U — Configuration: BOND RTU; Regulatory Status: In Vitro Diagnostic Use; Volume: 7ml (availability in Australia, Canada, New Zealand, Puerto Rico, Trinidad and Tobago, United States)