Antibody PA0406-U

polyclonal antibodyFFPE tissuesdiagnostic

Product overview
Antibody reagents directed against Calcitonin for immunohistochemistry (IHC). Available as BOND RTU (ready-to-use) and liquid concentrate formats. Clones: POLYCLONAL and CL1948. Intended for P (ENZYME) IHC in Head, Neck and Endocrine pathology. Volumes: 7ml (BOND RTU) and 1ml (liquid concentrate). Regulatory status: In Vitro Diagnostic Use.

Antigen background
Calcitonin (CT) is a 32–amino-acid peptide produced by parafollicular C cells of the thyroid. It inhibits osteoclast-mediated bone resorption and reduces serum calcium by actions on kidney and intestine. The CT/CGRP transcript yields either calcitonin or calcitonin gene‑related peptide (CGRP) depending on tissue-specific splicing. Elevated Calcitonin expression is a diagnostic marker for medullary thyroid carcinoma and related C‑cell pathology.

Disclaimer
For detection of Calcitonin in normal and neoplastic tissues as an adjunct to conventional histopathology. Use according to local regulations and the provided IFU.

Image caption
Human medullary thyroid carcinoma: immunohistochemical staining for Calcitonin (clone CL1948).

Products / Variants

• PA0406-U — 7ml Calcitonin Bond RTU Prim
  • Clone: POLYCLONAL
  • Pathology menu: Head, Neck and Endocrine
  • Configuration: BOND RTU
  • HD (High Definition): No
  • Use: P (ENZYME)
  • Species: Mouse
  • Regulatory Status: In Vitro Diagnostic Use
  • Volume: 7ml
• CALCITONIN-L-CE — 1ml NCL-L-Calcitonin
  • Clone: CL1948
  • Pathology menu: Head, Neck and Endocrine
  • Configuration: Liquid Concentrate
  • HD (High Definition): No
  • Use: P (ENZYME)
  • Species: Mouse
  • Regulatory Status: In Vitro Diagnostic Use
  • Volume: 1ml
• PA0406 — 7ml Calcitonin Bond RTU Prim
  • Clone: POLYCLONAL
  • Pathology menu: Head, Neck and Endocrine
  • Configuration: BOND RTU
  • HD (High Definition): No
  • Use: P (ENZYME)
  • Species: Mouse
  • Regulatory Status: In Vitro Diagnostic Use
  • Volume: 7ml
• CALCITONIN-L-U — 1ml NCL-L-Calcitonin
  • Clone: CL1948
  • Pathology menu: Head, Neck and Endocrine
  • Configuration: Liquid Concentrate
  • HD (High Definition): No
  • Use: P (ENZYME)
  • Species: Mouse
  • Regulatory Status: In Vitro Diagnostic Use
  • Volume: 1ml

Characteristics / Technical specifications

• Product name: Calcitonin
• Available configurations: BOND RTU and Liquid Concentrate
• Clones: POLYCLONAL; CL1948
• Intended use: P (ENZYME) immunohistochemistry
• Pathology menu: Head, Neck and Endocrine
• Species reactivity/source listed: Mouse
• Regulatory Status: In Vitro Diagnostic Use
• Available volumes: 1ml and 7ml
• Representative image caption: Human medullary thyroid carcinoma immunostaining for Calcitonin

Applications and performance

• Recommended use: IHC detection of Calcitonin in FFPE tissue sections.
• Primary applications: identification of C‑cell hyperplasia, medullary thyroid carcinoma and evaluation of neuroendocrine differentiation in head & neck endocrine lesions.
• Format guidance: use BOND RTU for automated Bond platforms; use liquid concentrate following dilution and protocol optimization.

Regulatory & documents

• Regulatory status: In Vitro Diagnostic Use
• Available downloads: SDS and IFU for each reference