Antibody Bcl-6

monoclonal antibodyfor researchdiagnostic

Antigen background
Bcl-6 is a proto-oncogene encoding a Krüppel-type zinc-finger transcription factor (~95 kDa). Expression is principally observed in germinal-center B cells and in related lymphomas. Chromosomal rearrangements at 3q27 involving Bcl-6 have been reported in non-Hodgkin lymphomas and are detected in approximately 33–45% of diffuse large B-cell lymphomas. Immunohistochemistry frequently demonstrates Bcl-6 nuclear expression in follicular lymphoma, diffuse large B-cell lymphoma, Burkitt lymphoma and nodular lymphocyte‑predominant Hodgkin disease.

Intended use / Disclaimer
This Bcl-6 Oncoprotein reagent is supplied for the detection of Bcl-6 antigen in normal and neoplastic tissues as an adjunct to conventional histopathology using non-immunologic histochemical stains. Follow the regulatory status indicated per SKU. Not for therapeutic use.

Available configurations / product variants

• SKU: BCL-6-564-L — 1ml NCL-L-Bcl-6-564 — Configuration: Liquid Concentrate — Volume: 1ml — Regulatory Status: Research Use Only
• SKU: BCL-6-564-L-CE — 1ml NCL-L-Bcl-6-564 — Configuration: Liquid Concentrate — Volume: 1ml — Regulatory Status: In Vitro Diagnostic Use
• SKU: PA0204 — 7ml Bcl-6 Bond RTU Primary — Configuration: BOND RTU — Volume: 7ml — Regulatory Status: In Vitro Diagnostic Use
• SKU: BCL-6-564-L-U — 1ml NCL-L-Bcl-6-564 — Configuration: Liquid Concentrate — Volume: 1ml — Regulatory Status: In Vitro Diagnostic Use
• SKU: PA0204-U — 7ml Bcl-6 Bond RTU Primary — Configuration: BOND RTU — Volume: 7ml — Regulatory Status: In Vitro Diagnostic Use

Additional product information

• Clone: LN22
• Pathology menu: Hematopathology
• Configuration: Liquid Concentrate or BOND RTU (depending on SKU)
• HD (High Definition): Yes
• Use: P (HIER)
• Source: Monoclonal
• Species of origin (antibody): Mouse

Technical specifications

• Antigen: Bcl-6 oncoprotein
• Clone: LN22
• Intended use (examples by SKU): Research Use Only or In Vitro Diagnostic Use
• Available volumes: 1 ml (liquid concentrate) and 7 ml (BOND RTU)
• Application: Immunohistochemistry (IHC), heat-induced epitope retrieval (HIER)
• Pathology category: Hematopathology
• Format: Liquid concentrate and ready-to-use (BOND RTU) options
• Antibody source: Mouse monoclonal
• High Definition (HD) compatible: Yes

Availability and replacement
Country-specific availability and information on replacement or discontinued SKUs are provided on the product page for each SKU.