Monoclonal antibody B-CAT-L-CE

antibodytissueimmunohistochemistry

Antigen background
Beta-Catenin is a cytoplasmic protein that binds the conserved tail of E-cadherin and is a component of the adherens junction. It supports Ca2+-dependent cell–cell adhesion, actin cytoskeleton anchoring and signal transmission. In addition, Beta-Catenin functions as a transcription effector in the Wnt signaling pathway. Nuclear localization detected by immunohistochemistry is an indicator of Wnt-pathway activation and is observed in various tumorigenic processes, notably colorectal cancer.

Disclaimer
This antibody is intended for the detection of Beta-Catenin in normal and neoplastic tissues by immunohistochemistry and should be used as an adjunct to standard histopathological methods and stains.

Image caption
Human colon polyp: immunohistochemical staining for Beta-Catenin. Note the abnormal translocation of the protein to the nucleus. Beta-Catenin: clone 17C2

Available products / configurations

• SKU: B-CAT-L-CE — 1ml NCL-L-B-CAT
  • Clone: 17C2
  • Pathology menu: Soft Tissue Pathology
  • Configuration: Liquid Concentrate
  • HD (High Definition): No
  • Use: P (HIER)
  • Source: Mono
  • Species: Mouse
  • Regulatory status: In Vitro Diagnostic Use
  • Volume: 1ml
• SKU: PA0083 — 7ml Beta-Catenin Bond RTU Primary
  • Clone: 17C2
  • Pathology menu: Soft Tissue Pathology
  • Configuration: BOND RTU
  • HD (High Definition): No
  • Use: P (HIER)
  • Source: Mono
  • Species: Mouse
  • Regulatory status: In Vitro Diagnostic Use
  • Volume: 7ml
• SKU: B-CAT-L-U — 1ml NCL-L-B-CAT
  • Clone: 17C2
  • Pathology menu: Soft Tissue Pathology
  • Configuration: Liquid Concentrate
  • HD (High Definition): No
  • Use: P (HIER)
  • Source: Mono
  • Species: Mouse
  • Regulatory status: In Vitro Diagnostic Use
  • Volume: 1ml
• SKU: PA0083-U — 7ml Beta-Catenin Bond RTU Primary
  • Clone: 17C2
  • Pathology menu: Soft Tissue Pathology
  • Configuration: BOND RTU
  • HD (High Definition): No
  • Use: P (HIER)
  • Source: Mono
  • Species: Mouse
  • Regulatory status: In Vitro Diagnostic Use
  • Volume: 7ml

Technical characteristics / specifications

• Product: Beta-Catenin primary antibody
• Clone: 17C2
• Species / source: Mouse monoclonal (Mono)
• Intended use: Primary antibody for IHC, P (HIER)
• Pathology menu: Soft Tissue Pathology
• Regulatory status: In Vitro Diagnostic Use
• Configurations available: Liquid Concentrate (1ml) and BOND RTU (7ml)
• Replacement information: replaces earlier B-CAT family items
• Available volumes: 1ml, 7ml
• HD (High Definition): No