Magnetic bead-based reagent KAPA HyperPure

for DNA library preparationfor RNA library preparationsample preparation

Product overview
KAPA HyperPure Beads offer a tunable solution for reaction purification and size selection in DNA and RNA next-generation sequencing (NGS) library construction workflows. They are ready-to-use, automation-friendly bead solutions optimized to remove adapters, adapter-dimers, primers, primer-dimers, nucleotides, salts, and enzymes while enabling reproducible size selection.

Benefits at a glance

• One product for multiple analytes (DNA and RNA)
• Seamless integration into NGS research workflows
• Tunable and highly reproducible size selection
• Fast, efficient reaction cleanups
• Automation-friendly and ready-to-use

Compatibility and workflow integration

• Optimized for DNA library prep workflows, including KAPA EvoPlus V2 Kits and KAPA EvoPrep Kits
• Optimized for RNA library prep workflows, including KAPA RNA EvoPrep Kits
• Comparable yields and size distribution to industry-leading suppliers
• Readily incorporated into existing automation applications

Performance highlights (figures summarized)
Figures in the product literature report superior recovery performance vs. a competitor for unfragmented human gDNA and for degraded FFPE human genomic DNA at recommended bead:sample ratios. Additional figures demonstrate tunable double-sided size selection (multiple bead-to-sample ratios) producing distinct fragment-size ranges post-fragmentation and post-amplification.

Available kit formats (examples shown on product page)

• KAPA HyperPure Beads Kit (5 mL) — EAN: 07613336170892
• KAPA HyperPure Beads Kit (30 mL) — EAN: 07613336170908
• KAPA HyperPure Beads Kit (60 mL) — EAN: 07613336170915
• KAPA HyperPure Beads Kit (4 x 60 mL) — EAN: 07613336170939
• KAPA HyperPure Beads Kit (450 mL) — EAN: 07613336170922

Shipping / Storage
Shipping
On dry ice or ice packs, dependent on the destination country

Storage
Immediately store at 2°C to 8°C in a constant-temperature refrigerator. Do not store at -15°C to -25°C. Light-sensitive and must be stored protected from light when not in use. When stored and handled correctly, KAPA HyperPure Beads will retain full functionality until the expiry date.

Intended use and regulatory status
For Research Use Only (RUO). Not for use in diagnostic procedures.

Technical specifications

• Product family: KAPA
• Denomination (model): KAPA HyperPure Beads
• Intended applications: Reaction purification and tunable size selection in NGS library construction (DNA and RNA)
• Formulation: Ready-to-use bead suspension, automation-friendly
• Key functions: Remove adapters, adapter-dimers, primers, primer-dimers, nucleotides, salts, enzymes; enable selection of fragment sizes of interest without bias
• Performance: Demonstrated superior recovery vs. competitor in DNA workflows (unfragmented and FFPE degraded DNA) and reproducible double-sided size selection across multiple bead-to-sample ratios
• Available pack sizes: 5 mL, 30 mL, 60 mL, 4 x 60 mL, 450 mL (see available kit formats for EANs)
• Shipping conditions: On dry ice or ice packs, dependent on destination
• Storage conditions: 2°C to 8°C; protect from light; do not freeze at -15°C to -25°C
• Regulatory/label: RUO (For Research Use Only)