Enzyme reagent kit DR1100

antigenfor diabetesfor GAD

Human glutamic acid decarboxylase 65 (hGAD65) is a key autoantigen in type 1 diabetes, an autoimmune disease resulting from the destruction of insulin-producing β cells in the pancreas Product Description Glutamic acid decarboxylase is the key rate-limiting enzyme for the inhibitory neurotransmitter γ-aminobutyric acid. It is composed of two isomers, GAD65 and GAD67. Anti-GAD65 antibodies are the main target antigen of anti-GAD antibodies in type 1 diabetes. Anti-GAD antibodies are an important immune marker of insulin-dependent diabetes (type 1 diabetes). The positive rate of anti-GAD antibodies in prediabetes and type 1 diabetes is 70-90%, and the positive rate is higher in older children and late-onset type 1 diabetes. Latent autoimmune diabetes in adults (LADA) is easily misdiagnosed as type 2 diabetes due to its insidious onset, slow progression, partial pancreatic β-cell function, and effective oral hypoglycemic drugs. Joint detection of anti-glutamic acid decarboxylase antibodies and anti-islet cell antibodies can help early identification of LADA. In addition, anti-GAD antibodies are associated with stiff-person syndrome, with a positive rate of 60-100% in this disorder. [INTENDED USE ] The kit has been designed for the quantitative determination of Glutamic acid decarboxylase65 calibrator(GAD65) in human serum. The method can be used for samples over the range of 2-2000IU/mL Testing method 1. Treat the calibrator as the sample to be tested, and place it in the sample loading area of the instrument after mixing. Note that when mixing Avoid air bubbles.