Globulin detection kit DR1031

virusbloodserum

Procollagen III, N-terminal propeptide (PIIINP) is used as a biomarker for increased collagen III-synthesis. [INTENDED USE ] The kit has been designed for the quantitative determination of Pepsinogen III N Terminal Peptide （PⅢNP）in human serum. The method can be used for samples over the range of 4-700 ng/mL Pepsinogen III N Terminal Peptide (PⅢNP) quantitative detection kit (CLIA) (hereinafter referred to as the kit) is used for in vitro quantitative detection of PⅢNP concentration in human serum. PⅢNP can effectively reflect the synthesis of collagen type Ⅲ. Its serum levels consistent with the degree of liver fibrosis and significantly correlated with serum γ- globulin levels. PⅢNP level is closely related with the activity of liver fibrosis which is valuable in the early diagnosis of liver fibrosis and the prognosis of chronic liver disease. PⅢNP in normal liver is the amino terminus polypeptide generated by the amino-terminal peptide cleavage which is secreted by the PIII out of the liver cell before deposition. During this process, PⅢNP and Ⅲ type N-terminal peptide showed equal concentration, and entered into the blood circulation. Therefore, PⅢNP concentration can be an indicator to detect PⅢNP synthesis. ⅢNP can be divided into four parts by chromatography: amino-terminal propeptide of 50KD, Coll of l0 KD (degradation part of the former), and the other two parts are the polymer propeptide dimer. With the development of liver fibrosis, PⅢNP of 50KD rises, and is with a positive correlation with the degree of cirrhosis, such as cirrhosis of the liver and liver fibrosis caused by virus and alcohol .