Human pepsinogens I (PGI) and II (PGII) are proenzymes of pepsin—an endoproteinase of gastric juice. PGI is secreted mainly by chief cells in the fundic mucosa , whereas PGII is also secreted by the pyloric glands and the proximal duodenal mucosa .
Product Description
Gastric cancer, one of the digestive system malignant tumors, with the characteristic of both high prevalence and high mortality, has become one of the most common diseases which damage human’s health and safety.
The number of patients with gastric cancer is increasing, and because the symptom of early gastric cancer is not so obvious, many patients are diagnosed with elderly gastric cancer.With the significant progress of medical treatment in recent years, many clinical observations showed that early diagnosis and treatment can effectively rise patients’ 5 year survival rate and improve their prognosis. Therefore, exploring the monitoring indexes of gastric cancer is beneficial to the early diagnosis and treatment of patients with gastric cancer.
Now we mainly use pathological examination under gastroscope to diagnose gastric cancer, but as it is an invasive operation and some patients are impossible to tolerate the operation, so it has certain limits in early gastric cancer diagnosis.To further explore the practical value of Serum Pepsinogen I/II, gastrin-17 in diagnosis and prognosis of gastric cancer, we examined and analyzed the indexes mentioned above in patients with gastric ulcer, patients with gastric cancer, postoperative patients, and healthy people to provide theoretical reference for early diagnosis and prognosis of gastric cancer.