High-throughput synthesis platform FLEX ISYNTH

microwave

Overview
Automated, parallel library synthesis and lead optimization for medicinal chemistry. Chemspeed’s fully automated, integrated FLEX ISYNTH is a flexible, modular and uncompromising automated solution that unlocks chemical space via faster, better and virtually unrestricted exploration of reaction space, reagent space and molecule space. The system supports fully automated reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.

Workflow
FLEX ISYNTH deck modularity provides versatility to execute a variety of synthesis workflows (conventional, microwave-assisted, photochemistry, reactive gas) in a fully automated fashion. The platform enhances efficiency and productivity (up to 100× in some examples) for transformations such as C–C and C–N coupling reactions, organometallic reactions (e.g. Grignard), alkylations, Diels–Alder reactions and transfer hydrogenations.

Benefits

• Fully automated, integrated reaction preparation, synthesis, work-up, analysis and output to storage vials for solid- and liquid-phase library synthesis and reaction screening.
• Easy-to-use disposable multi-functional, high-precision glass reactor arrays; reaction scales available from μL to mL.
• Glass reactor arrays with screwless and self-sealing opening/closing; mixing by shaking (up to 1,700 rpm), heating (up to 150°C) and cooling (down to −20°C); capable of refluxing, vacuum and inertization.
• Automated evaporation, liquid–liquid extraction, filtration, solid-phase extraction, crystallization and drying (work-up capabilities).
• Proprietary robotic tool exchange for flexible automation.
• Gravimetric solid handling spanning μg to g scales.
• Gravimetric liquid handling spanning μL to mL and mg to g scales.
• Chemistry-proven liquid handling features (pH control, filtration, heated needle extension).
• High throughput: examples include 24 / 48 / 96 (and larger) parallel reactions per run.
• Integrated sampling and analytics including benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS and NIR / MIR / DLS measurement cells.
• Ventilated hood for safe and conditioned operation.
• AUTOSUITE software for drag & drop experiment design and execution; supports custom Python device integration and connectivity to LIMS, ELN, data analysis and AI/ML closed-loop workflows.

Characteristics / technical specifications

• System: FLEX ISYNTH — flexible, modular automated library synthesis workstation.
• Workflow modes supported: conventional synthesis, microwave-assisted, photochemistry, reactive gas workflows, multistep synthesis.
• Reaction scales: micro‑litre (μL) to milli‑litre (mL).
• Reactor: disposable multi-functional high-precision glass reactor arrays with screwless self-sealing lids.
• Mixing: shaking up to ~1,700 rpm.
• Temperature: heating up to 150°C; cooling down to −20°C; supports reflux and vacuum.
• Work-up capabilities: evaporation, liquid–liquid extraction, filtration, solid-phase extraction (SPE), crystallization, drying.
• Handling: gravimetric solid handling (μg → g); gravimetric liquid handling (μL → mL; mg → g).
• Throughput: parallel runs (e.g. 24 / 48 / 96+ reactions per run).
• Analytics integration: benchtop online NMR, HPLC-MS, UPLC-MS, GC-MS, UV-VIS, NIR / MIR, DLS measurement cell.
• Automation: proprietary robotic tool exchange; automated sample collection and transfer to storage vials.
• Safety / environment: ventilated hood for conditioned and safe operation.
• Software: AUTOSUITE for experiment design (drag & drop), execution, reporting and integration with LIMS / ELN / AI workflows; supports Python custom device scripts.