Automatic sample preparation system FLEX AUTOPLANT

automatedfor researchfor research and development

Overview
The Chemspeed FLEX AUTOPLANT workstations enable high-throughput process R&D, optimization and scale-up for pharmaceuticals, agrochemicals, polymers, specialty chemicals, catalysts, electrode and photovoltaic materials, energy storage materials and related sectors. The system supports QbD and PAR-driven development workflows with integrated online/offline benchtop NMR for rapid chemical profiling and decision-making.

Key capabilities

• End-to-end process R&D, chemical development and scale-up
• Organic and inorganic synthesis including pressured reactions
• Preparative synthesis and crystallization workflows
• Automated sampling and integrated analytics (online/offline NMR)

Workflow (AUTOPLANT with integrated online / offline NMR)
AUTOPLANT executes automated multi-step sequences with integrated online/offline NMR. Typical automated steps include:

• Inertization
• Gravimetric dispensing of solids
• Volumetric dispensing of liquids
• Heating with mixing
• Sampling (direct injection or into NMR vial)
• Work-up operations (filtration, liquid/liquid extraction, SPE)
• Online/offline NMR analysis (flow cell or standard 5 mm tubes)

Benefits
Each reactor is individually controlled to provide precise continuous feeds and integrated analytics for scalable, industrially relevant process development. Highlights include:

• Multiple reactor volumes: 100 mL, 240 mL, 1,000 mL (per tank)
• Parallel throughput: up to 6 syntheses per run (prep, reaction, work-up, analysis)
• Exchangeable stirrer designs (anchor, twisted blade, gas‑entrainment)
• Mixing capability up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm (anchor stirrer)
• Flexible continuous feeds: liquids, liquefied gases and gases; multiple feeds per reactor
• Independent temperature and stirring control per reactor; active cooling enabling >130°C difference between adjacent reactors
• Internal and jacket temperature control; pressure capability up to 100 bar with safety installations
• Parallel calorimetry and viscosity acquisition; PAT interfaces (pH, UV‑VIS, IR, Raman, PSD, calorimetry)
• Optional Dean‑Stark trap, distillation bridge, vacuum for inertization/crystallization
• Ventilated hood for safe operation with sensitive or low‑temperature chemistries
• AUTOSUITE software: drag & drop experiment design, Python device support, LIMS/ELN integrations, data analysis and AI/ML closed‑loop workflows
• Integrated online benchtop NMR (examples: 80 MHz Fourier RxnLite) with sample injection port, 1D/2D spectra, multi‑nuclei support (1H/19F/13C/31P/29Si/11B) via flow cell or 5 mm tubes; permanent magnet (no cryogens)

Technical specifications

• Typical reactor volumes: 100 mL, 240 mL, 1,000 mL (total per tank)
• Parallel throughput: up to 6 syntheses per run (including prep, execution, work‑up, analysis)
• Mixing performance: up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm (anchor stirrer)
• Temperature control: independent per reactor; active cooling allowing >130°C difference between adjacent reactors
• Pressure capability: up to 100 bar (with appropriate safety installations)
• Feeds: precise continuous liquid, liquefied gas and gas feeds; multiple feeds per reactor and unlimited overhead access
• PAT connectivity: pH, UV‑VIS, IR, Raman, PSD, calorimetry and other in‑situ probes; gas consumption measurement
• Work‑up capabilities: filtration, liquid/liquid extraction, SPE, evaporation, distillation, Dean‑Stark trap
• Software: AUTOSUITE for drag & drop automation; integrations to LIMS/ELN and support for AI/ML closed‑loop workflows
• Integrated NMR: benchtop online/offline NMR (example: 80 MHz Fourier RxnLite), sample injection port, 1D/2D spectra, multi‑nuclei support, permanent magnet (no cryogens)