Robotized synthesis platform ISYNTH SPEEDCHEM

high-throughput

Overview
The ISYNTH SPEEDCHEM platform combines elevated temperature and autogeneous pressure to accelerate reaction rates for small-molecule, polymer, porous material and cathode material synthesis. Automated parallel synthesis is conducted in versatile well-plate formats using disposable glass vial/reactor arrays under superheated (van't Hoff) conditions, enabling shorter reaction times and often enhanced selectivity.

Benefits

• Fully automated, integrated synthesis including elevated-pressure operation in 96‑well plates: screening block safety up to 100 bar and jacket temperatures up to 250 °C; includes automated work-up and analysis.
• End-to-end reagent preparation for liquids and solids, multistep synthesis, work-up, purification, analysis and product transfer to storage.
• SPEEDCHEM operation (superheated conditions, e.g. ~40 °C above boiling point) can yield approximately 16× faster reactions, improved reagent solubility, reduced side reactions, higher yields and lower energy consumption.
• Disposable, high-precision glass reactor arrays in SBS/well-plate formats (e.g. 12×20 mL, 24×8 mL, 48×2 mL, 96×1 mL total volume).
• Dedicated automated well-plate pressure screening block for reactive gas chemistries (CATSCREEN) and superheated chemistries (SPEEDCHEM).
• Work-up options: liquid/liquid extraction, filtration, solid-phase extraction, crystallization and drying.
• Proprietary robotic tool exchange for flexible automation workflows.
• Gravimetric solid handling from micrograms to grams.
• Gravimetric liquid handling from milligrams to grams and volumetric dispensing from microliters to milliliters.
• Chemistry-capable liquid handling features: pH control, filtration, heated needle extension.
• High throughput: 12 / 24 / 48 / 96 parallel reactions per run.
• Integrated sampling and analytics: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR/MIR, DLS measurement cell.
• Optional ventilated, conditioned hood for sensitive or low-temperature chemistry and possible integration within a customized glove-box.
• AUTOSUITE software for drag & drop experiment design, Python scripting/custom device support, LIMS/ELN integration, data analysis and AI/ML closed-loop workflows.
• Optional integrated online benchtop NMR (examples: 80 MHz Fourier RxnLite) for advanced chemical profiling (1D/2D), online flow-cell acquisition or offline 5 mm sample tubes; permanent magnet design (no liquid nitrogen or helium required).

Workflow (typical automated modules)

• Volumetric dispensing (liquids)
• Gravimetric dispensing (solids)
• Shaking and heating under superheated / van't Hoff SPEEDCHEM conditions
• Sampling, analysis and automated work-up steps

Technical specifications

• Platform name: ISYNTH SPEEDCHEM
• Plate format: well-plate based (e.g. 96‑well) with disposable glass vial/reactor arrays
• Glass vial configurations: examples include 12×20 mL, 24×8 mL, 48×2 mL, 96×1 mL
• Maximum safety pressure (screening block): up to 100 bar
• Maximum jacket temperature: up to 250 °C
• Throughput: parallel reactions (12 / 24 / 48 / 96 per run)
• Solid handling: gravimetric from μg to g
• Liquid handling: gravimetric from mg to g and volumetric from μL to mL
• Work-up methods: L/L extraction, filtration, solid-phase extraction, crystallization, drying
• Analytics integrations: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR, DLS
• Software: AUTOSUITE for drag & drop experiment design, scripting (Python) and LIMS/ELN/AI/ML integration
• Optional modules: CATSCREEN pressure screening block, ventilated conditioned hood, benchtop NMR (e.g. 80 MHz Fourier RxnLite)