Fully automated sample preparation system Bruker Automation Package

laboratoryfor the pharmaceutical industrybenchtop

Overview
The preparation of NMR and LC‑MS samples is often manual, consuming skilled time and increasing risk of error. The FLEX SWILE NMR system automates gravimetric sample preparation with true one‑to‑one solid pick & decision dispense directly from source vials. The dispensing module combines Chemspeed’s overhead gravimetric tool design with an optional on‑deck analytical balance. Disposable glass SWIN tips eliminate cross‑contamination risk. SWIN tips are available in multiple diameters and are selected according to target mass. A tilt/shake rack conditions powders prior to pick‑up.

Key features

• High accuracy and precision by decision dispensing combined with on‑deck balance
• Dispensing range from hundreds of μg to ~5 mg with ~±10 μg resolution (with analytical balance)
• No cross‑contamination due to disposable SWIN glass tips
• No dead volume in solid transfer
• Fully inert materials in contact (glass)
• Unattended operation for higher throughput

Workflow
FLEX SWILE NMR — migrated workflow: FLEX SWILE NMR. The system supports direct dispensing into NMR tubes and LC vials and can be integrated into automated sample chains.

Benefits

• Robotic tool exchange interface for flexible tool combinations
• Ventilated hood option for conditioned atmosphere and safety
• Compact footprint (~90×90 cm) optimized for capacity and facility constraints
• Modular integration: on‑deck balance, tilt/shake rack, barcode reader, multigripper, tumble stirrer, shaking modules
• Automated dispensing into NMR tubes and LC vials; optional on‑deck balance for ~±10 μg resolution
• Gravimetric and volumetric liquid handling for dissolution with tumble stirrer or shaking modules
• AUTOSUITE software for drag & drop protocol design and integration with LIMS, ELN and common autosamplers (Bruker, Agilent, Shimadzu, Thermo, Waters)

Technical specifications

• Technology: SWILE automated gravimetric pick & decision dispense of solids from source vials
• Dispensing range: hundreds of μg up to ~5 mg
• Resolution: approximately ±10 μg with optional on‑deck analytical balance
• Consumables: disposable glass tips (SWIN) in multiple diameters to minimize cross‑contamination and dead volume
• Pre‑treatment: tilt/shake rack to loosen and tilt powder before pick‑up
• Materials in contact: fully inert (glass)
• Operation: unattended automation capability
• Integration options: on‑deck balance, barcode reader, multigripper, tumble stirrer, shaking modules, autosamplers
• Safety/environment: ventilated hood option for conditioned atmosphere
• Footprint: optimized compact footprint (approx. 3×3 ft / 90×90 cm)
• Software: AUTOSUITE for drag & drop experiment design, LIMS/ELN and instrument integration