Robotized synthesis platform FLEX AUTOPLANT

high-throughput

Overview
Quality by Design (QbD) and proven acceptable range (PAR) driven high-throughput process R&D for chemical development, preparative synthesis, work-up and analysis with integrated online or offline benchtop XRD.

Product
The Chemspeed FLEX AUTOPLANT workstations are designed for high-output experimentation to support development and optimization across pharmaceuticals, agrochemicals, polymers, specialty chemicals, catalysts, cathode and photovoltaic materials, storage materials and related fields.

• End-to-end process R&D, chemical development and scale-up
• Organic and inorganic synthesis, including pressured reactions
• Preparative synthesis workflows
• Controlled crystallization

Description
The FLEX AUTOPLANT enables automated execution of diverse workflows to replicate industrial production sequences. Modular reactor and feed configurations provide flexibility to optimize integrated reaction sequences and downstream processing steps, while preserving independent control for each reactor.

Benefits

• Individually controlled tank reactors (volumes: 100 mL, 240 mL, 1'000 mL) with precise, continuous feeds
• Throughput: up to 6 syntheses per run on a FLEX AUTOPLANT (including preparation, execution, work-up and analysis)
• Interchangeable stirrer geometries (anchor, twisted blade, gas-entrainment)
• Mixing for viscosities up to 80 Pa·s at 300 rpm and 30 Pa·s at 900 rpm (anchor stirrer)
• Multiple continuous liquid, liquefied gas and/or gas feeds per reactor and unlimited overhead access
• Independent temperature and stirring control per reactor (examples: capability for >130°C temperature difference with active cooling)
• Internal and jacket temperature control options
• Pressure capability up to 100 bar with corresponding safety installations
• Parallel high-performance calorimetry and viscosity measurements
• PAT interfaces for in-situ probes (pH, UV-VIS, IR, Raman, PSD, calorimetry)
• Gas consumption measurement
• Dean Stark trap and distillation bridge options
• Vacuum modes for inertization, crystallization and other operations
• Extraction, filtration, evaporation, crystallization and distillation functions
• Ventilated hood for safety and conditioned operation (sensitive or low-temperature chemistries)
• AUTOSUITE software — drag & drop experiment design with custom device scripting (e.g. Python); connectivity to LIMS, ELN, data analysis and AI/ML closed-loop workflows
• Integrated online benchtop XRD support (examples: Bruker D6 Phaser, Malvern Aeris) including XRD device, sample handover station and software/hardware integration

Technical specifications

• Model / series: FLEX AUTOPLANT
• Reactor volumes: 100 mL, 240 mL, 1'000 mL (tank reactors)
• Throughput: up to 6 syntheses per run (including preparation, execution, work-up, analysis)
• Mixing performance: up to 80 Pa·s at 300 rpm, 30 Pa·s at 900 rpm (anchor stirrer)
• Feeds: precise continuous feeds; multiple continuous liquid, liquefied gas and gas feeds per reactor
• Temperature control: independent per reactor; internal and jacket control; example capability of >130°C difference with active cooling
• Pressure capability: up to 100 bar with safety installations
• Analytical integration: PAT probes (pH, UV-VIS, IR, Raman, PSD, calorimetry); parallel calorimetry and viscosity data
• Accessories / functions: Dean Stark trap, distillation bridge, vacuum options, extraction, filtration, evaporation, crystallization, distillation
• Environment: ventilated hood for safety and conditioned operation
• Software: AUTOSUITE for drag & drop experiment design; connectivity to LIMS, ELN, data analysis and AI/ML closed-loop workflows
• Integrated XRD: supports benchtop online XRD devices (examples: Bruker D6 Phaser, Malvern Aeris) with sample handover and software/hardware integration