Automatic sample preparation system SWING CRYSTAL

for the pharmaceutical industryreagent dispensingfiltration

Overview
The SWING CRYSTAL solution provides accelerated, standardized crystallization, polymorph, salt and solubility screening in MTP-format blocks with a bottom glass plate for direct transfer to XRPD. The system combines patented overhead gravimetric dispensing/dosing technology with a range of crystallization plates and integrated software to standardize and digitize crystallization and polymorph screening.

Product description
Patented overhead gravimetric dispensing/dosing for precise liquid and solid delivery is combined with multiple MTP-format crystallization plates to enable high-throughput, reproducible screening workflows. The platform supports direct output to high-throughput XRPD and provides data interfaces for DoE, ML/AI, LIMS and ERP systems to streamline experiment tracking and analysis.

Workflows

• SWING CRYSTAL - Crystallization screening
  • Dispense API into MP 1
  • Dispense solvents into MP 1
  • Heat and shake to dissolve
  • Transfer filtration plate
  • Remove filtration plate
  • Hot transfer from MP 2 to CP 1, 2 & 3
  • Hot filtration into MP 2
  • Characterization (direct transfer to XRPD)
• SWING CRYSTAL - Cooling (crash or controlled)
• SWING CRYSTAL - Anti-solvent
• SWING CRYSTAL - Evaporation (fast or slow)
• SWING CRYSTAL - Slurry

Benefits

• Decrease in cost per sample up to 90+%.
• Increase in productivity by a factor of 10.
• Up to 192 crystallization experiments per run on MTP-based and other formats.
• Support for salt selection, polymorph screening, co-crystal and solubility screening, including agitation, pH and temperature gradients, filtration and controlled evaporation.
• Systematic evaluation of factors such as solvent choice (eluotropic series), concentration, evaporation rate, temperature, cooling rate and agitation on crystal form.
• Ability to run two different crystallization workflows simultaneously.
• Reliable and precise gravimetric dispensing tools for liquid and solid delivery.
• Different reactor/well sizes (from <1 mL to 100 mL in disposable formats and up to 1,000 mL in high-output process development reactors) enable screening and scale-up on the same platform.
• Easy data export to Excel and interfaces to external software.
• Integration with DoE, ML/AI, LIMS and ERP systems.

Software

• AUTOSUITE: Fast, flexible experiment automation to design, execute, analyze and report experiments. Prebuilt or custom workflows can be created via drag-and-drop tasks.
• ARKSUITE: Orchestrates laboratory workflows across systems and manual processes. Centralizes workflows, experiments, messaging, status and inventory management.

Technical specifications

• Solution name: SWING CRYSTAL.
• Patented overhead gravimetric dispensing/dosing for precise liquid and solid delivery.
• Supports MTP-format crystallization plates with bottom glass plate for direct XRPD transfer.
• Throughput: up to 192 crystallization experiments per run (MTP and other formats).
• Workflows supported: salt selection, polymorph screening, co-crystal, solubility screening, anti-solvent, cooling (crash or controlled), evaporation (fast or slow), slurry workflows.
• Reactor / well sizes: from <1 mL to 100 mL in disposable formats; up to 1,000 mL in high-output process development reactors for scale-up.
• Capabilities: agitation, pH control, temperature gradients, controlled cooling rates, controlled evaporation, filtration, hot transfer and hot filtration.
• Data output: direct output to HT XRPD; easy export to Excel and interfaces to external software.
• Integration: compatible with DoE, machine learning / AI workflows, LIMS and ERP systems.
• Ability to run two different crystallization workflows simultaneously.
• Includes software ecosystem (AUTOSUITE, ARKSUITE) for experiment automation and lab orchestration.