High-throughput synthesis platform ISYNTH PSW

for peptidesfor oligonucleotidesfor oligosaccharides

Overview
High-throughput library synthesis for molecular diversity and large-molecule discovery (e.g. medicinal chemistry) using disposable glass vials, reusable double‑jacket reactors, microwave reactors and photochemical glass reactors. Patented overhead gravimetric dispensing combined with disposable glass reactor arrays and intuitive software accelerates, standardizes and digitalizes (oligo)peptide, (oligo)nucleotide and (oligo)saccharide workflows. Chemspeed’s fully automated, integrated ISYNTH PSW is a modular solution for automated, parallel synthesis, work-up and analysis of diverse libraries.

Workflow
ISYNTH PSW supports fully automated execution including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage. Typical workflow steps include:

• Dispensing of solids and liquids (overhead gravimetric dispensing)
• Resin swelling
• Dispensing of reagents
• Coupling reactions
• Washings
• Deprotection

Benefits

• Fully automated, integrated reaction preparation, synthesis, work-up, analysis and transfer to storage vials for solid‑ and liquid‑phase library synthesis
• Disposable, multi‑functional high‑precision glass reactor arrays; reaction scales from μL to mL
• Glass reactor arrays with screwless, self‑sealing opening/closing; mixing by shaking (up to 17,000 rpm), heating (up to 150°C) and cooling (to −20°C / −70°C), reflux, vacuum and inertization
• Support for evaporation, L/L extraction, filtration, solid‑phase extraction, crystallization and drying
• Proprietary robotic tool exchange and flexible automation
• Gravimetric solid handling from μg to g and gravimetric liquid handling from mg to g / μL to mL
• Chemistry‑proven liquid handling features including pH control, filtration and heated needle extension
• High‑throughput options (examples: 24 / 48 / 96 parallel reactions per run)
• Ventilated, conditioned hood and optional glove‑box integration for sensitive, low‑temperature chemistries
• Sampling and integrated analytics such as benchtop online NMR, HPLC‑(MS), UPLC‑(MS), GC‑(MS), UV‑VIS, NIR/MIR and DLS measurement cell
• AUTOSUITE software with drag‑&‑drop experiment design and interfaces to LIMS, ELN, data analysis and AI/ML closed‑loop workflows
• Optional integrated benchtop NMR (e.g. 80 MHz Fourier RxnLite) with flow‑cell or 5 mm tube acquisition; supports multiple nuclei and 1D/2D experiments without cryogens

Caractéristiques / spécifications techniques

• Product / system name: ISYNTH PSW
• Automation: fully automated, integrated reaction preparation, synthesis, work‑up, purification, analysis and product transfer to storage vials
• Reactor types: disposable glass vials, reusable double‑jacket reactors, microwave reactors, photochemical glass reactors
• Reaction scale: micro‑ to millilitre scale (μL to mL)
• Reactor features: screwless, self‑sealing opening/closing; mixing by shaking (up to 17,000 rpm); heating to 150°C; cooling to −20°C / −70°C; reflux, vacuum, inertization, evaporation
• Unit operations supported: L/L extraction, filtration, solid‑phase extraction, crystallization, drying
• Dispensing/dosing: overhead gravimetric dispensing (patented); gravimetric solid handling from μg to g; gravimetric liquid handling from mg to g / μL to mL
• Throughput: parallel reactions (examples: 24 / 48 / 96 ...)
• Robotics: proprietary robotic tool exchange
• Environment: ventilated, conditioned hood; optional glove‑box integration for sensitive chemistries
• Analytics integration: benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV‑VIS, NIR / MIR, DLS measurement cell
• Software: AUTOSUITE for drag & drop experiment design; interfaces for LIMS, ELN, data analysis, AI/ML closed‑loop workflows; optional ARKSUITE orchestration
• Optional NMR: benchtop 80 MHz Fourier RxnLite style device, supports 1D/2D, multiple nuclei, flow‑cell or 5 mm tube acquisition, permanent magnet (no cryogens)